Liu Guoqiang, Pan Ruihao, Wei Yen, Tao Lei
The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Macromol Rapid Commun. 2021 Mar;42(6):e2000459. doi: 10.1002/marc.202000459. Epub 2020 Oct 1.
The Hantzcsh reaction is a robust four-component reaction for the efficient generation of 1,4-dihydropyridine (1,4-DHP) derivatives. Recently, this reaction has been introduced into polymer chemistry in order to develop polymers having 1,4-DHP structures in the main and/or side chains. The 1,4-DHP groups confer new properties/functions to the polymers. This mini-review summarizes the recent studies on the development of new functional polymers by using the Hantzsch reaction. Several synthetic approaches, including polycondensation, post-polymerization modification (PPM), monomer to polymer strategy, and one-pot strategy are introduced; different applications (protein conjugation, formaldehyde detection, drug carrier, and anti-bacterial adhesion) of the resulting polymers are emphasized. Meanwhile, the future development of the Hantzsch reaction in exploring new functional polymers is also discussed.
汉茨希反应是一种用于高效生成1,4 - 二氢吡啶（1,4 - DHP）衍生物的稳健的四组分反应。最近，该反应已被引入聚合物化学领域，以开发在主链和/或侧链中具有1,4 - DHP结构的聚合物。1,4 - DHP基团赋予聚合物新的性质/功能。这篇综述总结了利用汉茨希反应开发新型功能聚合物的最新研究。介绍了几种合成方法，包括缩聚、后聚合修饰（PPM）、单体到聚合物策略和一锅法策略；强调了所得聚合物的不同应用（蛋白质偶联、甲醛检测、药物载体和抗菌粘附）。同时，还讨论了汉茨希反应在探索新型功能聚合物方面的未来发展。
