Wu Haibo, Fu Changkui, Zhao Yuan, Yang Bin, Wei Yen, Wang Zhiming, Tao Lei
The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.
ACS Macro Lett. 2015 Nov 17;4(11):1189-1193. doi: 10.1021/acsmacrolett.5b00637. Epub 2015 Oct 15.
The tricomponent Biginelli reaction and the tetracomponent Hantzsch reaction which share the same reaction modules (aldehyde and β-ketone ester) have been found compatible. Therefore, a series of copolycondensates containing both 1,4-dihydropyridine (1,4-DHP) and 3,4-dihydropyrimidin-2(1)-one (3,4-DHPM) in the main chains via the simultaneous Hantzsch and Biginelli reactions have been facilely synthesized. The ratio of 1,4-DHP and 3,4-DHPM in the polymer congeners could be easily tuned by changing the feeding ratio of reactants, and the thermal properties of the obtained polymers are thereby adjusted. As the first attempt to prepare copolycondensate through the combination of two multicomponent reactions (MCRs), the current method revealed and utilized the interesting compatibility between MCRs, providing a new strategy to prepare multicomponent functional polymers.
已发现具有相同反应模块（醛和β-酮酯）的三组分Biginelli反应和四组分Hantzsch反应是兼容的。因此，通过同时进行Hantzsch反应和Biginelli反应，已轻松合成了一系列主链中同时含有1,4-二氢吡啶（1,4-DHP）和3,4-二氢嘧啶-2(1)-酮（3,4-DHPM）的共缩聚物。通过改变反应物的进料比，可以轻松调节聚合物同系物中1,4-DHP和3,4-DHPM的比例，从而调整所得聚合物的热性能。作为通过两种多组分反应（MCR）组合制备共缩聚物的首次尝试，当前方法揭示并利用了MCR之间有趣的兼容性，为制备多组分功能聚合物提供了一种新策略。
