Zhang Qingdong, Zhang Yaling, Zhao Yuan, Yang Bin, Fu Changkui, Wei Yen, Tao Lei
The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
ACS Macro Lett. 2015 Jan 20;4(1):128-132. doi: 10.1021/mz500734c. Epub 2015 Jan 8.
A novel multicomponent system has been constructed through the combination of Hantzsch reaction and reversible addition-fragmentation chain transfer (RAFT) polymerization in a one-pot manner. Compared to traditional stepwise methods, this one-pot system exhibits much more advantages to facilely and efficiently prepare well-defined poly(1,4-dihydropyridine)s (poly(1,4-DHP)s). A series of poly(1,4-DHP) derivatives have also been successfully prepared through this Hantzsch-RAFT system using different aldehydes as reactants, suggesting this system is a general and versatile approach to prepare well-defined functional polymers with 1,4-DHPs as side groups. Since 1,4-DHP derivatives are an important class of bioactive molecules in the pharmaceutical field, this simple method to prepare poly(1,4-DHP)s might have potential to prepare related functional polymers for biological and pharmaceutical applications.
通过将汉茨希反应与可逆加成-断裂链转移（RAFT）聚合一锅法相结合，构建了一种新型多组分体系。与传统的逐步方法相比，这种一锅法体系在简便高效地制备结构明确的聚（1,4-二氢吡啶）（聚（1,4-DHP））方面具有更多优势。使用不同的醛作为反应物，通过这种汉茨希-RAFT体系也成功制备了一系列聚（1,4-DHP）衍生物，这表明该体系是一种通用且多功能的方法，可用于制备以1,4-DHPs为侧基的结构明确的功能聚合物。由于1,4-DHP衍生物是药物领域一类重要的生物活性分子，这种制备聚（1,4-DHP）的简单方法可能具有制备用于生物和药物应用的相关功能聚合物的潜力。
