Chen Junying, Yuan Tian, Liu Zuozhen
Key Laboratory for Specially Functional Polymers and Related Technology of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Biomater Sci. 2020 Nov 21;8(22):6235-6245. doi: 10.1039/d0bm01101k. Epub 2020 Oct 2.
In the field of biomedicine, tissue bio-adhesives require the use of polymer materials with integrated functions to meet changing practical applications. However, the currently available tissue glues cannot balance mechanical properties and biocompatibility. Inspired by the conversion of lipoic acid from small molecular biological sources into high-performance supramolecular polymeric materials, thioctic acid (TA) was modified and polyethylene glycol diacrylate (PEGDA) was introduced. Successfully constructed a dry gel with antibacterial effect and promote infection for wound regeneration. The prepared modified lipoic acid is mixed with PEGDA, melted under mild heating and self-assembled, and then directly extruded on both sides of the wound. It quickly cures at 37 °C and firmly adheres to both sides of the wound. The material exhibits good processability and rapid self-healing ability due to the cross-linked structure of the internal disulfide bonds and thioether bonds. In addition, the characteristics of TA make the prepared xerogels have good tissue adhesion and good antibacterial properties. This work proposes an innovative material with mechanical strength and biocompatible tissue glue, which provides broad prospects for application in wound treatment.
在生物医学领域，组织生物粘合剂需要使用具有综合功能的聚合物材料来满足不断变化的实际应用需求。然而，目前可用的组织胶水无法平衡机械性能和生物相容性。受小分子生物来源的硫辛酸转化为高性能超分子聚合物材料的启发，对硫辛酸（TA）进行了改性，并引入了聚乙二醇二丙烯酸酯（PEGDA）。成功构建了具有抗菌作用并促进伤口再生感染的干凝胶。将制备的改性硫辛酸与PEGDA混合，在温和加热下熔融并自组装，然后直接挤出到伤口两侧。它在37°C下迅速固化并牢固地粘附在伤口两侧。由于内部二硫键和硫醚键的交联结构，该材料具有良好的加工性能和快速自愈能力。此外，TA的特性使制备的干凝胶具有良好的组织粘附性和良好的抗菌性能。这项工作提出了一种具有机械强度和生物相容性的创新型组织胶水材料，为伤口治疗应用提供了广阔前景。
