Yao Hang, Wu Ming, Lin Liwei, Wu Zhonglian, Bae Minjun, Park Sumin, Wang Shuli, Zhang Wang, Gao Jiefeng, Wang Dongan, Piao Yuanzhe
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002, PR China.
Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Mater Today Bio. 2022 Sep 15;16:100429. doi: 10.1016/j.mtbio.2022.100429. eCollection 2022 Dec.
The wound healing process is usually susceptible to different bacterial infections due to the complex physiological environment, which significantly impairs wound healing. The topical application of antibiotics is not desirable for wound healing because the excessive use of antibiotics might cause bacteria to develop resistance and even the production of super bacteria, posing significant harm to human well-being. Wound dressings based on adhesive, biocompatible, and multi-functional hydrogels with natural antibacterial agents have been widely recognized as effective wound treatments. Hydrogels, which are three-dimensional (3D) polymer networks cross-linked through physical interactions or covalent bonds, are promising for topical antibacterial applications because of their excellent adhesion, antibacterial properties, and biocompatibility. To further improve the healing performance of hydrogels, various modification methods have been developed with superior biocompatibility, antibacterial activity, mechanical properties, and wound repair capabilities. This review summarizes hundreds of typical studies on various ingredients, preparation methods, antibacterial mechanisms, and internal antibacterial factors to understand adhesive hydrogels with natural antibacterial agents for wound dressings. Additionally, we provide prospects for adhesive and antibacterial hydrogels in biomedical applications and clinical research.
由于复杂的生理环境，伤口愈合过程通常易受不同细菌感染，这会显著损害伤口愈合。局部应用抗生素对伤口愈合并不可取，因为过度使用抗生素可能会导致细菌产生耐药性，甚至产生超级细菌，对人类健康造成重大危害。基于具有天然抗菌剂的粘性、生物相容性和多功能水凝胶的伤口敷料已被广泛认为是有效的伤口治疗方法。水凝胶是通过物理相互作用或共价键交联的三维（3D）聚合物网络，因其优异的粘附性、抗菌性能和生物相容性，在局部抗菌应用中具有广阔前景。为了进一步提高水凝胶的愈合性能，人们开发了各种具有卓越生物相容性、抗菌活性、机械性能和伤口修复能力的改性方法。本综述总结了数百项关于各种成分、制备方法、抗菌机制和内部抗菌因素的典型研究，以了解用于伤口敷料的含天然抗菌剂的粘性水凝胶。此外，我们还展望了粘性抗菌水凝胶在生物医学应用和临床研究中的前景。
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