Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK.
Centre National de La Recherche Scientifique, UMR CNRS 5287, Bordeaux Cedex, France.
Neuropharmacology. 2020 Dec 15;181:108340. doi: 10.1016/j.neuropharm.2020.108340. Epub 2020 Sep 30.
Nearly 100 years after the discovery of serotonin, its role remains elusive. Modulation of serotonin transmission is considered in numerous central nervous system (CNS) diseases including depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson's disease, and Alzheimer's disease. The therapeutic strategies based on serotonin systems have evolved thanks to better identification of the involvement of serotonin in various diseases, the better use of animal models, a better understanding of the molecular environment of serotonin receptors, and ultimately the better understanding of the interaction of serotonin neurotransmission with other biological systems. Some 5-HT receptors are still the object of numerous investigations including 5-HT, 5-HT, and 5-HT receptor subtypes. It is noteworthy that the direction of research is moving towards a simultaneous action at multiple targets either through different 5-HT targets or the consideration of both 5-HT and other targets to achieve better therapeutic responses.
近 100 年来，尽管人们发现了血清素，但它的作用仍然难以捉摸。在包括抑郁症、焦虑症、精神分裂症、强迫症、成瘾、帕金森病和阿尔茨海默病在内的多种中枢神经系统疾病中，人们都考虑对血清素传递进行调节。得益于对血清素在各种疾病中的作用有了更好的认识、对动物模型的更好利用、对血清素受体的分子环境有了更深入的了解，以及对血清素神经传递与其他生物系统相互作用的更深入理解，基于血清素系统的治疗策略已经得到了发展。一些 5-HT 受体仍然是众多研究的对象，包括 5-HT1、5-HT2 和 5-HT4 受体亚型。值得注意的是，研究方向正朝着通过不同的 5-HT 靶点或同时考虑 5-HT 和其他靶点来同时作用于多个靶点的方向发展，以实现更好的治疗效果。
