实体瘤表达的靶向突变抗原的免疫受体的鉴定及临床应用
Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors.
作者信息
Pasetto Anna
机构信息
Department of Laboratory Medicine, Division of Clinical Microbiology, ANA FUTURA, Karolinska Institutet, 14152 Huddinge, Sweden.
出版信息
Cancers (Basel). 2020 Sep 30;12(10):2818. doi: 10.3390/cancers12102818.
Abstract
In the recent years, immunotherapy has achieved impressive results utilizing different approaches, from (chimeric antigen receptor) CAR-T cells directed against CD19 for the treatment of leukemia and lymphomas to the Nobel prize-winning strategy of check-point inhibition for the treatment of several solid tumors [...].
摘要
近年来，免疫疗法采用了不同的方法取得了令人瞩目的成果，从用于治疗白血病和淋巴瘤的针对CD19的嵌合抗原受体（CAR-T）细胞，到用于治疗多种实体瘤的获得诺贝尔奖的检查点抑制策略[……]
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