Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA.
Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA.
Urol Clin North Am. 2020 Nov;47(4):475-485. doi: 10.1016/j.ucl.2020.07.005. Epub 2020 Sep 9.
Cancer is a highly complex and heterogeneous disease and immunotherapy has shown promise as a therapeutic approach. The increased resolution afforded by single-cell analysis offers the hope of finding and characterizing previously underappreciated populations of cells that could prove useful in understanding cancer progression and treatment. Urologic and prostate cancers are inherently heterogeneous diseases, and the potential for single-cell analysis to help understand and develop immunotherapeutic approaches to treat these diseases is very exciting. In this review, we view cancer immunotherapy through a single-cell lens and discuss the state-of-the-art technologies that enable advances in this field.
癌症是一种高度复杂和异质的疾病，免疫疗法已显示出作为一种治疗方法的前景。单细胞分析提供的更高分辨率有望发现和描述以前未被充分认识的细胞群体，这可能有助于理解癌症的进展和治疗。泌尿系统和前列腺癌是固有异质性疾病，单细胞分析有可能帮助理解和开发免疫治疗方法来治疗这些疾病，这非常令人兴奋。在这篇综述中，我们从单细胞的角度来看待癌症免疫疗法，并讨论了推动该领域发展的最先进技术。
