男性不育的个性化医学

Personalized Medicine for the Infertile Male.

机构信息

Division of Urology, Department of Surgery, Brown University, 2 Dudley Street Suite 185, Providence, RI, USA.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

Urol Clin North Am. 2020 Nov;47(4):523-536. doi: 10.1016/j.ucl.2020.07.003. Epub 2020 Sep 2.

DOI:10.1016/j.ucl.2020.07.003

PMID:33008501

Abstract

Personalized medicine uses a patient's genotype, environment, and lifestyle choices to create a tailored diagnosis and therapy plan, with the goal of minimizing side effects, avoiding lost time with ineffective treatments, and guiding preventative strategies. Although most precision medicine strategies are still within the laboratory phase of development, this article reviews the promising technologies with the greatest potential to improve the diagnosis and treatment options for male infertility, including sperm cell transplantation, genomic editing, and new biomarker assays, based on the latest proteomic and epigenomic studies.

摘要

个性化医学利用患者的基因型、环境和生活方式选择来制定个性化的诊断和治疗计划，目标是最大限度地减少副作用，避免因无效治疗而浪费时间，并指导预防策略。尽管大多数精准医学策略仍处于实验室开发阶段，但本文基于最新的蛋白质组学和表观基因组学研究，综述了最有希望改善男性不育症诊断和治疗选择的有前途的技术，包括精子细胞移植、基因组编辑和新的生物标志物检测。