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与心脏手术相关的医源性主动脉夹层:一篇叙述性综述。

Iatrogenic Aortic Dissection Associated With Cardiac Surgery: A Narrative Review.

机构信息

Department of Anesthesiology, University of Kentucky, Lexington, KY.

Department of Anesthesiology, University of Kentucky, Lexington, KY.

出版信息

J Cardiothorac Vasc Anesth. 2021 Oct;35(10):3050-3066. doi: 10.1053/j.jvca.2020.07.084. Epub 2020 Aug 7.

Abstract

Iatrogenic aortic dissection (iAD) is a relatively rare but a life-threatening complication associated with cardiac surgery. All members of the team caring for cardiac surgical patients (surgeons, perfusionists, and anesthesiologists) must be familiar with this complication to minimize its incidence and improve outcome. The present narrative review focuses on iAD occurring intraoperatively and during the early postoperative period (within 1 month) of cardiac surgery. The review also addresses iAD that occurs late (beyond 1 month) after cardiac surgery and iAD associated with other procedures. iAD occurs in about 0.06% of cases when the ascending aorta is the site of arterial cannulation, in about 0.6% when the femoral or iliac arteries are used, and in about 0.5% when the axillary or subclavian arteries are used. Mortality is estimated to be 30% but is more than double if not recognized until the postoperative period. Site of origin of dissection is most commonly the arterial inflow cannula (∼33%). Other common sites are the aortic cross-clamp or partial occlusion clamp (∼29%) and the proximal saphenous vein anastomosis site (14%). Sixty percent of cases occur during coronary artery bypass graft (CABG) surgery and 17% during aortic valve surgery with or without CABG. iAD may be somewhat less common in off-pump versus on-pump CABG but is still not very rare. Risk factors, presentation, diagnosis, and management are reviewed in detail as is the key role of the use of echocardiography in the early diagnosis of iAD and for guiding its management.

摘要

医源性主动脉夹层(iAD)是一种相对罕见但危及生命的心脏手术相关并发症。所有照顾心脏手术患者的团队成员(外科医生、灌注师和麻醉师)都必须熟悉这种并发症,以尽量减少其发生率并改善预后。本叙述性综述重点关注心脏手术期间和术后早期(1 个月内)发生的 iAD。该综述还涉及心脏手术后晚期(1 个月后)发生的 iAD 和与其他手术相关的 iAD。当升主动脉为动脉插管部位时,iAD 的发生率约为 0.06%;当股动脉或髂动脉被使用时,iAD 的发生率约为 0.6%;当腋动脉或锁骨下动脉被使用时,iAD 的发生率约为 0.5%。死亡率估计为 30%,但如果在术后才被发现,则死亡率会增加一倍以上。夹层的起源部位最常见于动脉流入插管(约 33%)。其他常见部位是主动脉阻断钳或部分阻断钳(约 29%)和近端大隐静脉吻合部位(14%)。60%的病例发生在冠状动脉旁路移植术(CABG)期间,17%发生在主动脉瓣手术期间,无论是否同时进行 CABG。非体外循环与体外循环 CABG 相比,iAD 可能略不常见,但仍然不罕见。详细回顾了风险因素、表现、诊断和治疗,以及超声心动图在早期诊断 iAD 和指导其管理中的关键作用。

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