Stössel P
Can J Microbiol. 1987 May;33(5):461-4. doi: 10.1139/m87-077.
The influence of a series of related isoflavonoids on growth of the zoopathogenic yeast, Candida albicans, in liquid media was studied. The order of effectiveness was identical with that previously found for a range of phytopathogenic fungi. Minimum inhibitory concentration of phaseollinisoflavan, the most active test compound, was 250 microM for 3 days after inoculation. However, C. albicans resumed growth thereafter. Phaseollinisoflavan, 500 microM, did not inhibit but only delayed growth of the yeast. Tolerance of C. albicans to phaseollin and phaseollinisoflavan was based on nondegradative mechanism(s), while tolerance to glyceollin appeared to be based on detoxification.
研究了一系列相关异黄酮对致病性酵母白色念珠菌在液体培养基中生长的影响。其有效性顺序与先前在一系列植物病原真菌中发现的顺序相同。活性最高的受试化合物菜豆异黄烷醇的最低抑菌浓度在接种后3天为250微摩尔。然而，此后白色念珠菌恢复生长。500微摩尔的菜豆异黄烷醇并不抑制酵母生长，只是延迟其生长。白色念珠菌对菜豆素和菜豆异黄烷醇的耐受性基于非降解机制，而对大豆抗毒素的耐受性似乎基于解毒作用。
