Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL (YL, KV, LBC); Department of Health Education and Behavior, College of Health and Human Performance, University of Florida, Gainesville, FL (JWC).
J Addict Med. 2021;15(3):211-218. doi: 10.1097/ADM.0000000000000749.
We identified the patterns of cocaine use during individuals' heaviest use period by considering quantity, frequency, and duration simultaneously and examined the correlates and risk profile for these patterns.
Latent profile analysis was conducted among the 3117 individuals who reported lifetime use of cocaine in the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) with quantity, frequency, and duration used as indicators. Logistic regression analyses examined factors associated with subtype membership based on patterns of cocaine use and the relationships between these patterns and cocaine use disorder (CocUD) and its severity.
Four patterns were identified: a "low use" class (72.6%), a "moderate use" class (8.2%), a "daily use" class (17.9%), and a "very high quantity use" class (1.3%). Relative to non-Hispanic White and the "low use" class, non-Hispanic Black was associated with increased odds to be in the "moderate use" and "daily use" classes. Higher prevalence of smoking crack cocaine and poly-route use was observed among the "very high quantity use" class relative to other classes; increased risk of using other substances was associated with the "daily use" class. Higher levels of cocaine use were associated with higher risks of CocUD and worse severity compared to the "low use" class.
People who use cocaine are heterogeneous with different patterns of use and risks of CocUD. Reducing cocaine smoking and poly-route of use should be placed as the same priority as decreasing very high quantity of use in interventions.
我们通过同时考虑数量、频率和持续时间来确定个体使用可卡因高峰期的使用模式，并研究这些模式的相关性和风险特征。
在国家酒精和相关条件流行病学调查 III 期（NESARC-III）中，有 3117 名报告了可卡因终身使用的个体中进行潜在剖面分析，将使用量、频率和持续时间作为指标。逻辑回归分析根据可卡因使用模式，检查与亚型成员身份相关的因素以及这些模式与可卡因使用障碍（CocUD）及其严重程度之间的关系。
确定了四种模式：“低用量”类（72.6%）、“中等用量”类（8.2%）、“每日使用”类（17.9%）和“非常高用量”类（1.3%）。与非西班牙裔白人和“低用量”类相比，非西班牙裔黑人与“中等用量”类和“每日使用”类的比值增加有关。与其他类相比，“非常高用量”类中使用快克可卡因和多途径使用的比例更高；与“每日使用”类相关的是使用其他物质的风险增加。与“低用量”类相比，可卡因使用量较高与 CocUD 的风险增加和严重程度恶化有关。
使用可卡因的人具有不同的使用模式和 CocUD 风险，存在异质性。在干预措施中，减少可卡因吸食和多途径使用应与减少非常高的用量放在同等重要的位置。
