呼吸系统健康和炎症标志物——瑞典硬金属行业中接触钴。
Respiratory Health and Inflammatory Markers-Exposure to Cobalt in the Swedish Hard Metal Industry.
机构信息
Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, SE 701 82 Örebro, Sweden (Dr Lena Andersson, Ing-Liss Bryngelsson, Anders Johansson, Annette Ericsson, Per Vihlborg, Håkan Westberg); School of Medical Sciences, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden (Dr Lena Andersson, Dr Alexander Hedbrant, Dr Alexander Persson, Eva Särndahl, Håkan Westberg); Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden (Dr Lena Andersson, Dr Alexander Hedbrant, Dr Alexander Persson, Eva Särndahl, Håkan Westberg); Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden (Bengt Sjögren); Unit of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, PB 414, SE-405 30 Gothenburg, Sweden (Dr Leo Stockfelt).
出版信息
J Occup Environ Med. 2020 Oct;62(10):820-829. doi: 10.1097/JOM.0000000000001952.
OBJECTIVE
To study the relationship between inhalable dust and cobalt, and respiratory symptoms, lung function, exhaled nitric oxide in expired air, and CC16 in the Swedish hard metal industry.
METHODS
Personal sampling of inhalable dust and cobalt, and medical examination including blood sampling was performed for 72 workers. Exposure-response relationships were determined using logistic, linear, and mixed-model analysis.
RESULTS
The average inhalable dust and cobalt concentrations were 0.079 and 0.0017 mg/m, respectively. Statistically significant increased serum levels of CC16 were determined when the high and low cumulative exposures for cobalt were compared. Nonsignificant exposure-response relationships were observed between cross-shift inhalable dust or cobalt exposures and asthma, nose dripping, and bronchitis.
CONCLUSIONS
Our findings suggest an exposure-response relationship between inhalable cumulative cobalt exposure and CC16 levels in blood, which may reflect an injury or a reparation process in the lungs.
目的
研究瑞典硬金属行业中可吸入粉尘与钴，以及呼吸症状、肺功能、呼出气一氧化氮（FeNO）和 CC16 之间的关系。
方法
对 72 名工人进行可吸入粉尘和钴的个体采样以及医学检查，包括采血。使用逻辑、线性和混合模型分析来确定暴露反应关系。
结果
可吸入粉尘和钴的平均浓度分别为 0.079 和 0.0017mg/m。当比较高和低累积钴暴露时，发现 CC16 的血清水平显著升高。在跨班次可吸入粉尘或钴暴露与哮喘、流鼻涕和支气管炎之间未观察到显著的暴露反应关系。
结论
我们的研究结果表明，可吸入累积钴暴露与血液中的 CC16 水平之间存在暴露反应关系，这可能反映了肺部的损伤或修复过程。
Zotero 插件