Ashleigh E. Smith, Alliance for Research in Exercise Nutrition and Activity, Allied Health and Human Performance, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001. Tel: +618 8302 1735. Email:
J Nutr Health Aging. 2020;24(8):857-864. doi: 10.1007/s12603-020-1405-5.
Long-chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA) are essential nutrients and may be capable of delaying age-related cognitive decline. However, previous studies indicate that Australians are not meeting recommendations for LCn-3 PUFA intake. The current study therefore examined LCn-3 PUFA intake in an older Australia sample, as well as associations between LCn-3 PUFA intake and cognitive function.
Cross-sectional data were collected from 90 adults aged 50 to 80 years. LCn-3 PUFA intake was assessed using a food frequency questionnaire and red blood cell fatty acid profiles were used to calculate the Omega-3 Index (RBC n-3 index). Cognitive function was measured using Addenbrooke's Cognitive Examination-III.
Positive associations were observed between age and RBC n-3 index (b=0.06, 95% CI: 0.01 - 0.10, P=0.01), and age and LCn-3 PUFA intake from fish oil capsules (b=17.5, 95% CI: 2.4 - 32.5 mg/day, P=0.02). When adjusting for LCn-3 PUFA from fish oil capsules, the association between age and RBC n-3 index was no longer significant. No associations were observed between LCn-3 PUFA intake and cognitive function.
LCn-3 PUFA and fish oil consumption increased with age in this sample of older Australians, particularly due to supplement intake. However, LCn-3 PUFA intake was not associated with cognitive function.
长链 ω-3 多不饱和脂肪酸（LCn-3PUFA）是必需营养素，可能能够延缓与年龄相关的认知能力下降。然而，先前的研究表明，澳大利亚人没有达到 LCn-3PUFA 摄入量的建议。因此，本研究在一个较年长的澳大利亚样本中检查了 LCn-3PUFA 的摄入量，以及 LCn-3PUFA 摄入量与认知功能之间的关联。
从 90 名年龄在 50 至 80 岁的成年人中收集了横断面数据。使用食物频率问卷评估 LCn-3PUFA 的摄入量，并使用红细胞脂肪酸谱计算 ω-3 指数（RBCn-3 指数）。使用 Addenbrooke's 认知测验-III 测量认知功能。
观察到年龄与 RBCn-3 指数之间存在正相关（b=0.06，95%CI：0.01-0.10，P=0.01），年龄与鱼油胶囊中的 LCn-3PUFA 摄入量之间存在正相关（b=17.5，95%CI：2.4-32.5mg/天，P=0.02）。在调整鱼油胶囊中的 LCn-3PUFA 后，年龄与 RBCn-3 指数之间的关联不再显著。LCn-3PUFA 摄入量与认知功能之间没有观察到关联。
在这个较年长的澳大利亚样本中，LCn-3PUFA 和鱼油的摄入量随着年龄的增长而增加，尤其是由于补充剂的摄入。然而，LCn-3PUFA 摄入量与认知功能无关。
