Momoko Buyo CNS MSN RN, Department of Neuropsychiatry, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-0012 Japan, Telephone: +81-73-441-0759, Fax: +81-73-441-0769, E-mail:
J Nutr Health Aging. 2020;24(8):878-882. doi: 10.1007/s12603-020-1412-6.
This is a cross-sectional study of relation between metabolic syndrome and cognitive function in community-dwelling non-demented older adults in Japan. We examine the effect of metabolic syndrome and its components on global cognitive function. We also aim to clarify differences of specific cognitive domains between the subjects with and without metabolic syndrome.
We studied 2150 subjects aged between 60 and 90 years whose scores on mini mental state examination (MMSE) were over 23 points. We analyzed difference in MMSE scores between the subjects with and without metabolic syndrome. Logistic regression analysis was performed with MMSE score as the dependent variable and metabolic syndrome components as the independent variable adjusted with age. We also examined differences in attention, logical memory, and verbal and category fluency between the subjects with and without metabolic syndrome.
MMSE scores were not significantly different between subjects with and without metabolic syndrome. In logistic regression analysis, the score of MMSE was significantly negatively associated with triglycerides in males and significantly negatively associated with abdominal circumference in females. Subjects with metabolic syndrome showed significantly lower performance of attention tasks compared to subjects without metabolic syndrome.
Our results suggest that in community-dwelling non-demented Japanese older adults, attention but not global cognitive function may be impaired by metabolic syndrome. Inverted association between some components of metabolic syndrome and global cognitive function indicate necessity of further studies on the relation between undernutrition and cognitive function.
本研究旨在探讨日本社区居住的非痴呆老年人群中代谢综合征与认知功能之间的关系。我们检验了代谢综合征及其组分对总体认知功能的影响。我们还旨在阐明代谢综合征患者与非代谢综合征患者之间特定认知领域的差异。
我们研究了 2150 名年龄在 60 至 90 岁之间、迷你精神状态检查（MMSE）评分超过 23 分的受试者。我们分析了代谢综合征患者与非代谢综合征患者之间 MMSE 评分的差异。使用 MMSE 评分作为因变量，将代谢综合征组分作为自变量进行逻辑回归分析，并进行了年龄调整。我们还检查了代谢综合征患者与非代谢综合征患者之间注意力、逻辑记忆、言语和类别流畅性的差异。
代谢综合征患者与非代谢综合征患者的 MMSE 评分无显著差异。在逻辑回归分析中，MMSE 评分在男性中与甘油三酯呈显著负相关，在女性中与腰围呈显著负相关。与非代谢综合征患者相比，代谢综合征患者的注意力任务表现明显较差。
我们的研究结果表明，在日本社区居住的非痴呆老年人群中，代谢综合征可能会损害注意力而非总体认知功能。代谢综合征某些组分与总体认知功能之间的反向关联表明，有必要进一步研究营养不良与认知功能之间的关系。
