Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
J Vet Intern Med. 2020 Nov;34(6):2447-2453. doi: 10.1111/jvim.15916. Epub 2020 Oct 2.
In humans, Enterococcus spp. urinary tract infections (UTI) are commonly associated with urinary catheter-induced urothelial inflammation but this is not the case in dogs.
HYPOTHESIS/OBJECTIVES: To identify risk factors predisposing dogs to enterococcal bacteriuria.
Seventy dogs with Enterococcus spp. bacteriuria (case) and 70 dogs with Enterococcus coli bacteriuria (control).
A single center retrospective case-control study with subjects and controls identified by a medical records search for Enterococcus spp. (subject) or E coli (control) bacteriuria from January 1, 2014 to December 31, 2017. Cases and controls were balanced with respect to average age and weight. Binary logistic regression was used to estimate and test whether the odds of having Enterococcus spp. bacteriuria (instead of E coli) were associated with the presence of any given characteristic.
A history of recurrent bacteriuria was significantly more common in Enterococcus spp. cases than in E coli controls (odds ratio [OR]: 2.07; 95% confidence interval [CI]: 1.04-4.16, P = .04). Comorbidities associated with the presence of Enterococcus spp. bacteriuria included lower urinary tract (LUT) anatomic abnormalities (OR: 2.94; 95% CI: 1.17-8.10, P = .02), urolithiasis (P = .01), and the presence of LUT neoplasia (P = .04). Small frequencies (n = 12 and n = 6, respectively) compromise our ability to precisely estimate the genuine OR for the latter 2 characteristics.
If the identified risk factors promote Enterococcus spp. colonization in dogs via induced LUT inflammation similar to people then Enterococcus spp. bacteriuria could be a sentinel for underlying LUT inflammation.
在人类中，肠球菌属尿路感染（UTI）通常与导尿管引起的尿路上皮炎症有关，但在狗中并非如此。
假设/目的：确定使狗易患肠球菌菌尿的危险因素。
70 只患有肠球菌菌尿的狗（病例）和 70 只患有大肠埃希菌菌尿的狗（对照）。
一项单中心回顾性病例对照研究，通过病历搜索，于 2014 年 1 月 1 日至 2017 年 12 月 31 日，确定肠球菌属（病例）或大肠埃希菌（对照）菌尿的病例和对照。病例和对照在平均年龄和体重方面是平衡的。使用二元逻辑回归来估计和检验肠球菌属菌尿（而非大肠埃希菌菌尿）的可能性是否与任何特定特征的存在有关。
与大肠埃希菌对照组相比，肠球菌属病例中反复发生菌尿的病史更为常见（比值比[OR]：2.07；95%置信区间[CI]：1.04-4.16，P=.04）。与肠球菌属菌尿存在相关的合并症包括下尿路（LUT）解剖异常（OR：2.94；95% CI：1.17-8.10，P=.02）、尿路结石（P=.01）和 LUT 肿瘤的存在（P=.04）。由于小频率（分别为 n=12 和 n=6），我们无法准确估计后 2 个特征的真实比值比。
如果确定的危险因素通过诱导的 LUT 炎症促进犬肠球菌属定植，类似于人类，那么肠球菌属菌尿可能是潜在 LUT 炎症的一个指标。
