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心力衰竭治疗观念的转变——综述

Changing ideas in the treatment of heart failure--an overview.

作者信息

Poole-Wilson P A

出版信息

Cardiology. 1987;74 Suppl 1:53-7. doi: 10.1159/000174268.

Abstract

Patients with heart failure should stop smoking, maintain an optimal weight and limit their intake of salt. Alcohol abuse should be avoided. The detection and early treatment of hypertension appears to have had a major impact in preventing heart failure. Diuretics revolutionized the treatment of congestive heart failure and their proper and appropriate use can alleviate peripheral and pulmonary oedema. Diuretics should not be overused and care should be taken to avoid hypokalaemia. Controversy surrounds the use of digoxin in patients in sinus rhythm; the drug should be used in patients in atrial fibrillation. The use of an inotropic drug may be harmful in the presence of coronary artery disease. A reduction in the current use of digoxin might be of benefit to many patients with heart failure. When the drug is prescribed it should be used in a therapeutic and not homeopathic dose. Recent interest has been directed toward the use of vasodilators and the angiotensin-converting enzyme inhibitors in patients with heart failure. In my opinion, these drugs should be used after patients have been treated with thiazide and loop diuretics. Vasodilators are particularly beneficial in acute heart failure or in patients with chronic heart failure when the symptoms are related to fluid overload and volume expansion. The cause of symptoms in patients with chronic heart failure optimally treated with diuretics is controversial. Shortness of breath may not be simply related to the left atrial pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

心力衰竭患者应戒烟、保持理想体重并限制盐的摄入量。应避免酗酒。高血压的检测和早期治疗似乎对预防心力衰竭产生了重大影响。利尿剂彻底改变了充血性心力衰竭的治疗方法,正确合理使用可缓解外周和肺水肿。利尿剂不应过度使用,应注意避免低钾血症。对于窦性心律患者使用地高辛存在争议;该药物应用于房颤患者。在存在冠状动脉疾病的情况下使用正性肌力药物可能有害。减少目前地高辛的使用量可能对许多心力衰竭患者有益。开具该药物时应以治疗剂量而非顺势疗法剂量使用。最近人们对心力衰竭患者使用血管扩张剂和血管紧张素转换酶抑制剂产生了兴趣。在我看来,这些药物应在患者接受噻嗪类和袢利尿剂治疗后使用。血管扩张剂在急性心力衰竭或慢性心力衰竭患者症状与液体超负荷和容量扩张相关时特别有益。用利尿剂进行最佳治疗的慢性心力衰竭患者症状的原因存在争议。呼吸急促可能不仅仅与左心房压力有关。(摘要截至于250字)

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