Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Int J Gynaecol Obstet. 2021 May;153(2):239-247. doi: 10.1002/ijgo.13404. Epub 2020 Nov 2.
To assess the changes of spot urinary sodium and potassium and blood pressure (BP) throughout pregnancy and their correlations in southern Thailand.
A longitudinal study was conducted in southern Thailand from March 2018 to November 2019. Spot urinary excretion of sodium per creatinine (U[Na ]/[Cr]), potassium per creatinine (U[K ]/[Cr]) and U[Na ]/[K ] ratios, and BP were measured at four time points throughout pregnancy. A one-way analysis of variance with repeated measures and Bonferroni correction with post hoc analysis was used to identify significant differences between time points. The correlations were measured using Pearson's correlation coefficients.
A total of 327 pregnant women were included. Both systolic and diastolic BPs decreased gradually from up to 14 weeks of pregnancy to 18-22 weeks and then increased until 30-34 weeks. Mean spot U[Na ]/[Cr] ratios did not significantly change during the study period. Mean spot U[K ]/[Cr] ratios gradually increased, and spot U[Na ]/[K ] ratios gradually decreased. The correlation of spot U[Na ]/[Cr] and U[K ]/[Cr] ratios with BPs was weakly negative at all four time points.
Spot U[Na ]/[Cr] and U[K ]/[Cr] ratios are inversely correlated with BPs; weak correlations are found among pregnant women in southern Thailand. Further research in different populations is required to confirm its correlation and broader use.
评估泰国南部孕妇整个孕期尿钠和钾的变化及与血压（BP）的相关性。
这是一项 2018 年 3 月至 2019 年 11 月在泰国南部进行的纵向研究。在整个孕期的四个时间点测量尿钠与肌酐比值（U[Na ]/[Cr]）、尿钾与肌酐比值（U[K ]/[Cr]）和 U[Na ]/[K ]比值以及 BP。采用重复测量的单向方差分析和事后 Bonferroni 校正分析来确定时间点之间的差异。采用 Pearson 相关系数来测量相关性。
共纳入 327 名孕妇。收缩压和舒张压从怀孕 14 周到 18-22 周逐渐下降，然后一直升高至 30-34 周。研究期间，尿钠与肌酐比值的平均值没有明显变化。尿钾与肌酐比值的平均值逐渐升高，尿钠与肌酐比值逐渐降低。四个时间点的尿钠与肌酐比值和尿钾与肌酐比值与 BP 均呈弱负相关。
尿钠与肌酐比值和尿钾与肌酐比值与 BP 呈负相关；在泰国南部的孕妇中，相关性较弱。需要在不同人群中进一步研究以确认其相关性并扩大其应用。
