Hooft van Huysduynen Eveline J C, Hulshof Paul J M, van Lee Linde, Geelen Anouk, Feskens Edith J M, van 't Veer Pieter, van Woerkum Cees J M, de Vries Jeanne H M
1Division of Human Nutrition,Wageningen University,PO Box 8129 (Bode 62, HNE),6700 EV Wageningen,The Netherlands.
2Division of Strategic Communication,Wageningen University,Wageningen,The Netherlands.
Public Health Nutr. 2014 Nov;17(11):2505-11. doi: 10.1017/S1368980014001177. Epub 2014 Jun 9.
The most accurate method to estimate Na and K intakes is to determine 24 h urinary excretions of these minerals. However, collecting 24 h urine is burdensome. Therefore it was studied whether spot urine could be used to replace 24 h urine samples.
Participants collected 24 h urine and kept one voiding sample separate. Na, K and creatinine concentrations were analysed in both 24 h and spot urine samples. Also 24 h excretions of Na and K were predicted from spot urine concentrations using the Tanaka and Danish methods.
In 2011 and 2012, urine samples were collected and brought to the study centre at Wageningen University, the Netherlands.
Women (n 147) aged 19-26 years.
According to p-aminobenzoic acid excretions, 127 urine collections were complete. Correlations of Na:creatinine, K:creatinine and Na:K between spot urine and 24 h urine were 0·68, 0·57 and 0·64, respectively. Mean 24 h Na excretion predicted with the Tanaka method was higher (difference 21·2 mmol/d, P<0·001) than the measured excretion of 131·6 mmol/d and mean 24 h Na excretion predicted with the Danish method was similar (difference 3·2 mmol/d, P=0·417) to the measured excretion. The mean 24 h K excretion predicted with the Tanaka method was higher (difference 13·6 mmol/d, P<0·001) than the measured excretion of 66·8 mmol/d. Bland-Altman plots showed large individual differences between predicted and measured 24 h Na and K excretions.
The ratios of Na:creatinine and K:creatinine in spot urine were reasonably well associated with their respective ratios in 24 h urine and appear to predict mean 24 h Na excretion of these young, Caucasian women.
估计钠和钾摄入量的最准确方法是测定这些矿物质的24小时尿排泄量。然而，收集24小时尿液很麻烦。因此，研究了随机尿是否可用于替代24小时尿液样本。
参与者收集24小时尿液，并单独保留一份排尿样本。分析24小时尿液和随机尿样本中的钠、钾和肌酐浓度。还使用田中方法和丹麦方法根据随机尿浓度预测钠和钾的24小时排泄量。
2011年和2012年，收集尿液样本并送至荷兰瓦赫宁根大学的研究中心。
19 - 26岁的女性（n = 147）。
根据对氨基苯甲酸排泄量，127次尿液收集是完整的。随机尿与24小时尿液中钠:肌酐、钾:肌酐和钠:钾的相关性分别为0·68、0·57和0·64。用田中方法预测的24小时钠平均排泄量高于测量排泄量131·6 mmol/d（差值21·2 mmol/d，P<0·001），用丹麦方法预测的24小时钠平均排泄量与测量排泄量相似（差值3·2 mmol/d，P = 0·417）。用田中方法预测的24小时钾平均排泄量高于测量排泄量66·8 mmol/d（差值13·6 mmol/d，P<0·001）。布兰德 - 奥特曼图显示预测的和测量的24小时钠和钾排泄量之间存在较大个体差异。
随机尿中钠:肌酐和钾:肌酐的比值与24小时尿液中各自的比值有较好的相关性，似乎可以预测这些年轻白种女性的24小时钠平均排泄量。
