Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland; Institute for Infectious Diseases, Faculty of Medicine, University of Berne, Friedbühlstrasse 51, 3010, Berne, Switzerland.
Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland.
Exp Parasitol. 2020 Dec;219:108013. doi: 10.1016/j.exppara.2020.108013. Epub 2020 Oct 1.
Alveolar echinococcosis (AE) is a deadly parasitic disease that requires lifelong treatment with albendazole. Development of host immunity is pivotal with regard to the clinical outcome of AE, but its influence on conventional albendazole treatment is unknown. Using T-cell deficient athymic nude mice, we demonstrated that functional immunity is required for albendazole to be efficacious against murine AE. These results call for attention given the increasing number of immunocompromised patients with AE.
细粒棘球蚴病（AE）是一种致命的寄生虫病，需要终身用阿苯达唑治疗。宿主免疫的发展对于 AE 的临床结果至关重要，但它对常规阿苯达唑治疗的影响尚不清楚。我们使用 T 细胞缺陷的先天性无胸腺裸鼠证明了功能免疫对于阿苯达唑治疗小鼠 AE 的有效性是必需的。鉴于患有 AE 的免疫功能低下患者数量不断增加，这些结果值得关注。
