Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Exp Mol Pathol. 2020 Dec;117:104550. doi: 10.1016/j.yexmp.2020.104550. Epub 2020 Oct 1.
MicroRNAs (miRNAs) are transcripts with sizes of about 22 nucleotides, which are produced through a multistep process in the nucleus and cytoplasm. These transcripts modulate the expression of their target genes through binding with certain target regions, particularly 3' suntranslated regions. They are involved in the pathogenesis of several kinds of cancers, such as glioblastoma. Several miRNAs, including miR-10b, miR-21, miR-17-92-cluster, and miR-93, have been up-regulated in glioblastoma cell lines and clinical samples. On the other hand, expression of miR-7, miR-29b, miR-32, miR-34, miR-181 family members, and a number of other miRNAs have been decreased in this type of cancer. In the current review, we explain the role of miRNAs in the pathogenesis of glioblastoma through providing a summary of studies that reported dysregulation of these epigenetic effectors in this kind of brain cancer.
MicroRNAs (miRNAs) 是大小约为 22 个核苷酸的转录物，通过核和细胞质中的多步过程产生。这些转录物通过与某些靶标区域，特别是 3' 端非翻译区域结合，调节其靶基因的表达。它们参与了多种癌症的发病机制，如脑胶质瘤。几种 miRNA，包括 miR-10b、miR-21、miR-17-92 簇和 miR-93，在脑胶质瘤细胞系和临床样本中上调。另一方面，miR-7、miR-29b、miR-32、miR-34、miR-181 家族成员和许多其他 miRNA 的表达在这种癌症中降低。在本综述中，我们通过总结报道这些表观遗传效应物在这种脑癌中失调的研究，解释了 miRNA 在脑胶质瘤发病机制中的作用。
