Department of Pharmacy, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.
Halal Research Center of IRI, FDA, Tehran, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
Eur J Pharmacol. 2021 Jan 5;890:173617. doi: 10.1016/j.ejphar.2020.173617. Epub 2020 Oct 1.
Atherosclerotic plaque formation, destabilization and eventual rupture leads to the acute cardiovascular events including myocardial infarction and stroke. Emodin (PubChem CID#3220), (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei. This molecule has anti-oxidant, anti-inflammatory, anti-proliferative, anti-apoptotic and lipid-modulating effects. Experimental studies have demonstrated that emodin attenuates and stabilizes atherosclerotic plaques. In this mini-review, we provide a summary of the pharmacological actions of emodin in regulating vascular function and atherosclerosis, highlighting the therapeutic potential of this phytochemical in patients with cardiovascular disease.
动脉粥样硬化斑块的形成、不稳定和最终破裂会导致急性心血管事件，包括心肌梗死和中风。大黄素（PubChem CID#3220），（1,3,8-三羟基-6-甲基蒽醌-9,10-二酮）是一种从传统中药大黄的根茎中分离得到的具有药理活性的成分。该分子具有抗氧化、抗炎、抗增殖、抗凋亡和调节脂质的作用。实验研究表明，大黄素可减轻和稳定动脉粥样硬化斑块。在这篇综述中，我们总结了大黄素在调节血管功能和动脉粥样硬化方面的药理作用，强调了这种植物化学物质在心血管疾病患者中的治疗潜力。
