Meng Tianwei, Li Xinghua, Li Chengjia, Liu Jiawen, Chang Hong, Jiang Nan, Li Jiarui, Zhou Yabin, Liu Zhiping
Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Department of Pharmacy, Baotou Medical College, Baotou, Inner Mongolia, China.
Front Pharmacol. 2022 Sep 30;13:997598. doi: 10.3389/fphar.2022.997598. eCollection 2022.
Atherosclerosis (AS) is a prevalent arteriosclerotic vascular disease that forms a pathological basis for coronary heart disease, stroke, and other diseases. Inflammatory and oxidative stress responses occur throughout the development of AS. Treatment for AS over the past few decades has focused on administering high-intensity statins to reduce blood lipid levels, but these inevitably damage liver and kidney function over the long term. Natural medicines are widely used to prevent and treat AS in China because of their wide range of beneficial effects, low toxicity, and minimal side effects. We searched for relevant literature over the past 5 years in databases such as PubMed using the keywords, "atherosclerosis," "traditional Chinese medicine," "natural medicines," "inflammation," and "oxidative stress." We found that the PI3K/AKT, TLR4, JAK/STAT, Nrf2, MAPK, and NF-κB are the most relevant inflammatory and oxidative stress pathways in AS. This review summarizes studies of the natural alkaloid, flavonoid, polyphenol, saponin, and quinone pathways through which natural medicines used to treat AS. This study aimed to update and summarize progress in understanding how natural medicines treat AS inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment.
动脉粥样硬化（AS）是一种常见的动脉硬化性血管疾病，是冠心病、中风和其他疾病的病理基础。在AS的整个发展过程中都会发生炎症和氧化应激反应。在过去几十年中，AS的治疗主要集中在使用高强度他汀类药物来降低血脂水平，但从长期来看，这些药物不可避免地会损害肝肾功能。天然药物因其具有广泛的有益作用、低毒性和最小的副作用，在中国被广泛用于预防和治疗AS。我们在过去5年中使用关键词“动脉粥样硬化”、“中药”、“天然药物”、“炎症”和“氧化应激”在PubMed等数据库中搜索了相关文献。我们发现PI3K/AKT、TLR4、JAK/STAT、Nrf2、MAPK和NF-κB是AS中最相关的炎症和氧化应激途径。本综述总结了天然生物碱、黄酮类、多酚类、皂苷类和醌类途径的研究，通过这些途径天然药物用于治疗AS。本研究旨在更新和总结在理解天然药物如何治疗AS炎症和氧化应激相关信号通路方面的进展。我们还计划为未来AS治疗的新药开发创建一个信息库。
