Catalano Alessia, Ceramella Jessica, Iacopetta Domenico, Marra Maria, Conforti Filomena, Lupi Francesca R, Gabriele Domenico, Borges Fernanda, Sinicropi Maria Stefania
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona 4, 70126 Bari, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Foods. 2024 Jul 8;13(13):2155. doi: 10.3390/foods13132155.
Since ancient times, L. (AV) has attracted scientific interest because of its multiple cosmetic and medicinal properties, attributable to compounds present in leaves and other parts of the plant. The collected literature data show that AV and its products have a beneficial influence on human health, both by topical and oral use, as juice or an extract. Several scientific studies demonstrated the numerous biological activities of AV, including, for instance, antiviral, antimicrobial, antitumor, and antifungal. Moreover, its important antidepressant activity in relation to several diseases, including skin disorders (psoriasis, acne, and so on) and prediabetes, is a growing field of research. This comprehensive review intends to present the most significant and recent studies regarding the plethora of AV's biological activities and an in-depth analysis exploring the component/s responsible for them. Moreover, its morphology and chemical composition are described, along with some studies regarding the single components of AV available in commerce. Finally, valorization studies and a discussion about the metabolism and toxicological aspects of this "Wonder Plant" are reported.
自古以来，L. (AV) 因其多种美容和药用特性而吸引了科学界的关注，这些特性归因于植物叶子和其他部位所含的化合物。收集到的文献数据表明，AV 及其产品无论是局部使用还是口服（如制成果汁或提取物），都对人体健康有有益影响。多项科学研究证明了 AV 具有多种生物活性，例如抗病毒、抗菌、抗肿瘤和抗真菌活性。此外，其在包括皮肤疾病（牛皮癣、痤疮等）和糖尿病前期等多种疾病方面的重要抗抑郁活性，是一个不断发展的研究领域。本综述旨在介绍关于 AV 众多生物活性的最重要和最新研究，并深入分析探索其相关活性成分。此外，还描述了其形态和化学成分，以及一些关于市售 AV 单一成分的研究。最后，报告了对这种“神奇植物”的增值研究以及关于其代谢和毒理学方面的讨论。
