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Therapeutic Strategies for SARS-CoV-2 acting on ACE-2.

作者信息

Vitiello A, Ferrara F

机构信息

Clinical Pharmacologist, Pharmaceutical department, Usl Umbria 1, A.Migliorati street, 06132, Perugia, Italy.

Hospital Pharmacist Manager, Pharmaceutical department, Usl Umbria 1, A.Migliorati street, 06132, Perugia, Italy.

出版信息

Eur J Pharm Sci. 2021 Jan 1;156:105579. doi: 10.1016/j.ejps.2020.105579. Epub 2020 Sep 30.

DOI:10.1016/j.ejps.2020.105579
PMID:33010419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7526529/
Abstract
摘要

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Eur J Pharmacol. 2020 Sep 15;883:173373. doi: 10.1016/j.ejphar.2020.173373. Epub 2020 Jul 15.
2
The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2 : Anti-inflammatory and anti-fibrotic therapy could solve the lung complications of the infection?吡非尼酮在抗击由 SARS-CoV-2 引起的炎症和纤维化状态中的附加价值：抗炎和抗纤维化治疗能否解决感染的肺部并发症？
Eur J Clin Pharmacol. 2020 Nov;76(11):1615-1618. doi: 10.1007/s00228-020-02947-4. Epub 2020 Jun 27.
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Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension.血管紧张素转化酶抑制剂改善合并高血压的 COVID-19 患者的临床结局。
Emerg Microbes Infect. 2020 Dec;9(1):757-760. doi: 10.1080/22221751.2020.1746200.
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Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.新型冠状病毒（COVID-19）感染中枢神经系统的证据：组织分布、宿主-病毒相互作用及潜在神经嗜性机制。
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998. doi: 10.1021/acschemneuro.0c00122. Epub 2020 Mar 13.
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Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.血管紧张素转换酶2（ACE2）作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的受体：分子机制与潜在治疗靶点
Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.
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Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.冠状病毒刺突蛋白和宿主 ACE2 受体的组成和分化预测了 SARS-CoV-2 的潜在中间宿主。
J Med Virol. 2020 Jun;92(6):595-601. doi: 10.1002/jmv.25726. Epub 2020 Mar 11.
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Efficiency and specificity of RAAS inhibitors in cardiovascular diseases: how to achieve better end-organ protection?RAAS 抑制剂在心血管疾病中的疗效和特异性：如何实现更好的靶器官保护？
Hypertens Res. 2017 Nov;40(11):903-909. doi: 10.1038/hr.2017.65. Epub 2017 Jul 6.
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Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.组织肾素-血管紧张素-醛固酮系统：药物治疗的靶点。
Annu Rev Pharmacol Toxicol. 2010;50:439-65. doi: 10.1146/annurev.pharmtox.010909.105610.
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Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.盐皮质激素受体阻滞剂可增加充血性心力衰竭患者的血管紧张素转换酶2活性。
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