Ahmadi Amirhossein, Hosseini-Nami Samira, Abed Ziaeddin, Beik Jaber, Aranda-Lara Liliana, Samadian Hadi, Morales-Avila Enrique, Jaymand Mehid, Shakeri-Zadeh Ali
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175-861, Iran.
Finetech in Medicine Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Drug Discov Today. 2020 Dec;25(12):2182-2200. doi: 10.1016/j.drudis.2020.09.026. Epub 2020 Oct 1.
The high prescribed dose of anticancer drugs and their resulting adverse effects on healthy tissue are significant drawbacks to conventional chemotherapy (CTP). Ideally, drugs should have the lowest possible degree of interaction with healthy cells, which would diminish any adverse effects. Therefore, an ideal scenario to bring about improvements in CTP is the use of technological strategies to ensure the efficient, specific, and selective transport and/or release of drugs to the target site. One practical and feasible solution to promote the efficiency of conventional CTP is the use of ultrasound (US). In this review, we highlight the potential role of US in combination with lipid-based carriers to achieve a targeted CTP strategy in engineered smart drug delivery systems.
抗癌药物的高处方剂量及其对健康组织产生的不良影响是传统化疗（CTP）的显著缺点。理想情况下，药物与健康细胞的相互作用程度应尽可能低，这将减少任何不良影响。因此，实现CTP改进的理想方案是使用技术策略来确保药物向靶位点的高效、特异性和选择性转运和/或释放。提高传统CTP效率的一个切实可行的解决方案是使用超声（US）。在本综述中，我们强调了超声与脂质载体联合在工程化智能药物递送系统中实现靶向CTP策略的潜在作用。
