Abulimiti Muyasha, Dai Shiqin, Mitsuhiro Ebara, Sugawara Yu, Li Yinuo, Sakurai Hideyuki, Matsumoto Yoshitaka
Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan.
Research Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan.
Nanomaterials (Basel). 2025 Aug 6;15(15):1205. doi: 10.3390/nano15151205.
This study investigated the evolving trends, current research hotspots, and future directions of radiotherapy combined with nanobiomaterials through a bibliometric analysis. Publications related to nanobiomaterials used in radiotherapy between 2004 and 2024 were retrieved from the Web of Science Core Collection database and analyzed using VOSviewer, R, and CiteSpace. China emerged as the leading contributor, accounting for 1051 publications (50.41%), followed by the USA. Liu Zhuang is the most productive author in this field. American Chemical Society (ACS) Nano published the most influential articles and accumulated the highest number of citations. Advanced Targeted Therapies in Cancer: Drug Nanocarriers, the Future of Chemotherapy was the most cited, with 1255 citations. Citation bursts have revealed emerging research trends in targeted delivery, cellular studies, co-delivery strategies, immunogenic cell death, polymeric nanoparticles, tumor research, and drug delivery systems, indicating potential avenues for future research. Over the past two decades, nanomaterials for radiotherapy have gained substantial attention. Key areas of focus include enhancing the efficacy of radiotherapy, achieving targeted drug delivery, minimizing adverse effects, and integrating nanomaterials with other therapeutic modalities. Future investigations are expected to improve the precision of radiotherapy, augment radiation effects, and optimize the tumor microenvironment.
本研究通过文献计量分析，探讨了放射治疗与纳米生物材料相结合的发展趋势、当前研究热点及未来方向。从科学网核心合集数据库中检索了2004年至2024年间与放射治疗中使用的纳米生物材料相关的出版物，并使用VOSviewer、R和CiteSpace进行分析。中国成为主要贡献者，占1051篇出版物（50.41%），其次是美国。刘庄是该领域产出最多的作者。美国化学学会（ACS）的《纳米》发表了最具影响力的文章，累计被引次数最高。《癌症的先进靶向治疗：药物纳米载体，化疗的未来》被引次数最多，达1255次。文献共被引分析揭示了靶向递送、细胞研究、共递送策略、免疫原性细胞死亡、聚合物纳米颗粒、肿瘤研究和药物递送系统等新兴研究趋势，表明了未来研究的潜在途径。在过去二十年中，用于放射治疗的纳米材料受到了广泛关注。重点关注的关键领域包括提高放射治疗的疗效、实现靶向药物递送、最小化不良反应以及将纳米材料与其他治疗方式相结合。未来的研究有望提高放射治疗的精度、增强辐射效果并优化肿瘤微环境。
