COVID-19 患者临床结局与性别的相关性：一项 1190 例病例的回顾性分析。
Association of sex with clinical outcomes in COVID-19 patients: A retrospective analysis of 1190 cases.
机构信息
Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Surgical Intensive Care Unit, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
出版信息
Respir Med. 2020 Nov;173:106159. doi: 10.1016/j.rmed.2020.106159. Epub 2020 Sep 28.
BACKGROUND
The outbreak of COVID-19 caused by SARS-CoV-2 has been a pandemic. The objective of our study was to explore the association between sex and clinical outcomes in patients with COVID-19.
METHODS
Detailed clinical data including clinical characteristics, laboratory tests, imaging features and treatments of 1190 cases of adult patients with confirmed COVID-19 were retrospectively analyzed. Associations between sex and clinical outcomes were identified by multivariable Cox regression analysis.
RESULTS
There were 635 (53.4%) male and 555 (46.6%) female patients in this study. Higher rates of acute kidney injury (5.5% vs. 2.9%, p = 0.026), acute cardiac injury (9.1% vs. 4.3%, p = 0.001), and disseminated intravascular coagulation (2.5% vs. 0.7%, P = 0.024) were observed in males. Compared with female patients, male patients with COVID-19 had a higher inhospital mortality rate (15.7% vs. 10.3%, p = 0.005). However, Cox regression analysis showed that sex did not influence inhospital mortality of COVID-19 patients.
CONCLUSIONS
Male sex was associated with a worse prognosis of COVID-19, but it seems not to be an independent prognostic factor.
背景
由 SARS-CoV-2 引起的 COVID-19 疫情已经大流行。我们的研究目的是探讨 COVID-19 患者的性别与临床结局之间的关系。
方法
回顾性分析了 1190 例成人确诊 COVID-19 患者的详细临床数据，包括临床特征、实验室检查、影像学特征和治疗方法。采用多变量 Cox 回归分析确定性别与临床结局之间的关系。
结果
本研究中，男性患者 635 例（53.4%），女性患者 555 例（46.6%）。男性患者急性肾损伤（5.5%比 2.9%，p=0.026）、急性心脏损伤（9.1%比 4.3%，p=0.001）和弥散性血管内凝血（2.5%比 0.7%，P=0.024）的发生率更高。与女性患者相比，COVID-19 男性患者的院内死亡率更高（15.7%比 10.3%，p=0.005）。然而，Cox 回归分析显示，性别并不影响 COVID-19 患者的院内死亡率。
结论
男性与 COVID-19 的预后较差相关，但似乎不是独立的预后因素。
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