疫苗接种状况对住院 COVID-19 患者临床结局的影响。
Impact of vaccination status on clinical outcomes of hospitalized COVID-19 patients.
机构信息
Clinical Research Development Center, School of Medicine, Shahid Rahnemoon Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
BMC Infect Dis. 2024 Feb 23;24(1):254. doi: 10.1186/s12879-024-09139-w.
INTRODUCTION
It is important to identify the relationship between the COVID-19 vaccination status and the prognosis of this disease in hospitalized patients to gain a more accurate picture of their status and the effect of vaccination, as well as take necessary measures to improve their medical care. Thus, the present study was conducted to investigate the relationship between the vaccination status of hospitalized COVID-19 patients and the disease severity index in terms of clinical, imaging, and laboratory criteria.
METHODS
This research is a descriptive-analytical cross-sectional study. the study population consisted of patients with a positive RT-PCR test for coronavirus, admitted to COVID-19 departments of teaching hospitals in Yazd, Iran, during two months in the sixth peak of COVID-19. The patients' data comprised demographic information (age, sex, and underlying disease), clinical information (length of hospital stay, length of ICU stay, and vaccination status), disease outcome (mortality and intubation), laboratory information (ESR, CRP, and NLR), and imaging information (lung involvement percentage), and finally, the relationship between patients' vaccination status and disease severity indices were analyzed with the chi-square test, independent t-test, and logistic regression analysis at a 95% confidence interval (CI).
FINDINGS
According to research findings, the duration of hospitalization was 5.25 ± 2.34 and 6.11 ± 3.88 days in groups of patients with complete and incomplete vaccination, respectively (P = 0.003). The lengths of ICU stay were 6 ± 4.63 and 5.23 ± 3.73 days in both groups of patients admitted to the ICU (P = 0.395). Furthermore, there were significant relationships between the ICU admission rates, endotracheal intubation, mortality rate, the lung involvement score in the chest CT scan, and the NLR with the vaccination status.Multivariate regression analysis indicated that DM, IHD, NLR, CT scan score and vaccination status were related to patients' in-hospital mortality.
CONCLUSION
Complete vaccination of COVID-19 led to a milder disease in terms of clinical, imaging, and laboratory criteria of patients and decreased the possibility of hospitalization in ICUs, intubation, and mortality in patients.
简介
识别 COVID-19 疫苗接种状况与住院患者疾病预后之间的关系对于更准确地了解他们的状况和疫苗接种效果非常重要，并采取必要措施改善他们的医疗护理。因此，本研究旨在调查住院 COVID-19 患者的疫苗接种状况与临床、影像学和实验室标准方面的疾病严重程度指数之间的关系。
方法
这是一项描述性分析性的横断面研究。研究人群包括在伊朗亚兹德教学医院 COVID-19 科住院的经 RT-PCR 检测冠状病毒呈阳性的患者，在 COVID-19 的第六个高峰期的两个月内。患者的数据包括人口统计学信息（年龄、性别和基础疾病）、临床信息（住院时间、入住 ICU 时间和疫苗接种状况）、疾病结局（死亡率和插管）、实验室信息（ESR、CRP 和 NLR）和影像学信息（肺部受累百分比），最后，使用卡方检验、独立 t 检验和逻辑回归分析在 95%置信区间（CI）分析患者的疫苗接种状况与疾病严重程度指数之间的关系。
结果
根据研究结果，完全接种和不完全接种疫苗的患者的住院时间分别为 5.25±2.34 和 6.11±3.88 天（P=0.003）。入住 ICU 的两组患者的 ICU 入住时间分别为 6±4.63 和 5.23±3.73 天（P=0.395）。此外，ICU 入院率、气管插管、死亡率、胸部 CT 扫描的肺部受累评分和 NLR 与疫苗接种状态之间存在显著关系。多变量回归分析表明，糖尿病、冠心病、NLR、CT 扫描评分和疫苗接种状态与患者住院期间的死亡率有关。
结论
COVID-19 完全接种疫苗可使患者的疾病在临床、影像学和实验室标准方面减轻，降低患者入住 ICU、插管和死亡的可能性。
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