Division of Infectious Diseases, University of North Carolina, CB 7030, 130 Mason Farm Road, Chapel Hill, NC 27599, USA.
University of Queensland Centre for Clinical Research, Royal Brisbane & Women's Hospital Campus, Building 71/918, Herston, Queensland 4029, Australia.
Infect Dis Clin North Am. 2020 Dec;34(4):709-722. doi: 10.1016/j.idc.2020.08.002. Epub 2020 Sep 30.
Multidrug-resistant bacteria are among the most important current threats to public health. Typically, they are associated with nosocomial infections. However, some have become prevalent causes of community-acquired infections, such as Neisseria gonorrhoeae, Shigella, Salmonella, and Streptococcus pneumoniae. The community spread of multidrug-resistant bacteria is also a crucial development. An important global threat on the horizon is represented by production of carbapenemases by community-acquired hypervirulent Klebsiella pneumoniae. Such strains have already been found in Asia, Europe, and North America. Prevention of further community spread of multidrug-resistant bacteria is of the utmost importance, and will require a multidisciplinary approach involving all stakeholders.
耐多药细菌是当前对公众健康最重要的威胁之一。它们通常与医院获得性感染有关。然而,一些耐多药细菌已经成为社区获得性感染的常见原因,如淋病奈瑟菌、志贺氏菌、沙门氏菌和肺炎链球菌。耐多药细菌的社区传播也是一个关键的发展。社区获得性高毒力肺炎克雷伯菌产生碳青霉烯酶是一个重要的全球性威胁。这种菌株已经在亚洲、欧洲和北美发现。防止耐多药细菌进一步在社区传播至关重要,这将需要一个涉及所有利益相关者的多学科方法。