Speech Pathology Department, John Hunter Hospital, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia; University of Newcastle, Newcastle, NSW, Australia.
Speech Pathology Department, John Hunter Hospital, Newcastle, NSW, Australia.
J Allergy Clin Immunol Pract. 2021 Feb;9(2):897-905. doi: 10.1016/j.jaip.2020.09.034. Epub 2020 Oct 1.
Laryngeal disorders can contribute to disease burden in severe asthma yet the nature of laryngeal disorders in severe asthma is poorly understood.
The aim of this study was to examine laryngeal function in patients with severe asthma.
A cross-sectional observational study involving 97 participants compared laryngeal function in patients with severe asthma (n = 53) with patients with laryngeal disorders of vocal cord dysfunction/inducible laryngeal obstruction (n = 16) and muscle tension dysphonia (n = 14), and with healthy controls (n = 13). A pre-post pilot study of speech pathology intervention for laryngeal symptoms was then provided to 11 participants with severe asthma and laryngeal dysfunction.
Laryngeal dysfunction was common in severe asthma. The majority of participants with severe asthma (87%) had laryngeal dysfunction, which affected respiration, phonation, or both. Three distinct patterns of laryngeal dysfunction in severe asthma were identified: (1) phonatory laryngeal dysfunction, (2) respiratory laryngeal dysfunction, and (3) combined laryngeal dysfunction. Laryngeal hypersensitivity and impaired voice measures were common in severe asthma. Patient-reported outcome measures improved after therapy, and laryngeal dysfunction improved in 7 (64%) participants.
Laryngeal dysfunction affects respiration and phonation in severe asthma. It requires identification and treatment to minimize its impact on asthma symptoms.
喉部疾病可导致重度哮喘患者的疾病负担增加，但重度哮喘患者的喉部疾病性质尚不清楚。
本研究旨在检查重度哮喘患者的喉部功能。
一项涉及 97 名参与者的横断面观察性研究比较了重度哮喘患者（n=53）、声带功能障碍/可诱导性喉阻塞（n=16）和肌肉紧张性发音障碍（n=14）患者的喉部功能与健康对照组（n=13）的喉部功能。然后，对 11 名有喉部功能障碍的重度哮喘患者进行了言语病理学干预喉部症状的预-后试点研究。
重度哮喘患者中喉部功能障碍很常见。大多数重度哮喘患者（87%）存在影响呼吸或发音或两者均受影响的喉部功能障碍。在重度哮喘中确定了三种不同类型的喉部功能障碍：（1）发声性喉部功能障碍，（2）呼吸性喉部功能障碍，（3）混合性喉部功能障碍。重度哮喘患者中常见的是喉高敏性和声音测量受损。治疗后患者报告的结果测量指标有所改善，7 名（64%）患者的喉部功能障碍得到改善。
喉部功能障碍影响重度哮喘患者的呼吸和发音。需要识别和治疗以最大程度地减少其对哮喘症状的影响。
