Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Photodiagnosis Photodyn Ther. 2020 Dec;32:102037. doi: 10.1016/j.pdpdt.2020.102037. Epub 2020 Oct 2.
This is a systematic review and meta-analysis on the effectiveness of Photodynamic Therapy (PDT) in Bowen's Disease (BD), with further summary of the data from all randomized controlled trials (RCTs).
Relevant data were extracted after conducting a literature search via PubMed, Embase, Scopus, the Cochrane Library, CNKI, and Wanfang databases, from inception until 31 July 2019. Meta-analyses of the data were performed using RevMan V.5.3. A total of 392 published RCTs related to the efficacy of PDT in BD treatment were identified. The papers were screened for duplicates and excluded based on title and abstract. Subsequently, 85 full-text articles were thoroughly reviewed and finally, data from 446 patients with 1147 skin lesions across 12 eligible studies were collated.
Our findings revealed significant differences between the efficacies of PDT and other treatments, where a higher lesion reduction rate was observed after the first treatment session following PDT (P < 0.00001, Z = 4.98). PDT was found to be more effective than 5-fluorouracil (P < 0.00001, Z = 4.42) and cryotherapy (P = 0.008, Z = 2.67). However, there were no significant differences in recurrence rates following treatments with PDT, cryotherapy, and 5-fluorouracil.
This systematic review and meta-analysis confirms and collates data from all RCTs pertaining to the efficacy of PDT for BD treatment. Our study has reiterated that PDT is more effective than 5-fluorouracil and cryotherapy for the treatment of BD.
这是一项关于光动力疗法（PDT）治疗 Bowen 病（BD）有效性的系统评价和荟萃分析，同时对所有随机对照试验（RCT）的数据进行了总结。
通过检索 PubMed、Embase、Scopus、Cochrane 图书馆、中国知网（CNKI）和万方数据库，我们从建库至 2019 年 7 月 31 日，提取了相关数据。使用 RevMan V.5.3 对数据进行荟萃分析。共检索到 392 篇关于 PDT 治疗 BD 疗效的已发表 RCT 研究。首先筛选标题和摘要排除重复文献，然后对 85 篇全文文献进行仔细阅读，最终纳入 12 项研究的 446 例患者共 1147 处皮损的数据。
我们的研究结果表明，PDT 与其他治疗方法的疗效存在显著差异，PDT 治疗后第一次治疗时皮损减少率更高（P < 0.00001，Z = 4.98）。PDT 比 5-氟尿嘧啶（P < 0.00001，Z = 4.42）和冷冻疗法（P = 0.008，Z = 2.67）更有效。然而，PDT、冷冻疗法和 5-氟尿嘧啶治疗后的复发率没有显著差异。
这项系统评价和荟萃分析证实并汇总了所有 RCT 关于 PDT 治疗 BD 的疗效数据。我们的研究再次证实，PDT 比 5-氟尿嘧啶和冷冻疗法更有效治疗 BD。
