Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2020 Dec;32:102035. doi: 10.1016/j.pdpdt.2020.102035. Epub 2020 Oct 2.
The aim of the present 6-months' follow-up study was to assess the influence of single versus multiple sessions of photodynamic therapy (PDT) as adjunct to scaling and root planning (SRP) on periodontopathogenic bacteria in patients with periodontitis.
Forty-five patients with periodontitis were included. The patients were randomly divided into 3 groups. In groups 1 (n = 15), 2 (n = 15) and 3 (n = 15), the patients under went SRP with PDT at (a) baseline; (b) baseline and after 1-month; and (c) baseline and after 1- and 3-months. Peri-implant plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL) and marginal bone loss (MBL) were measured at baseline and 6-months follow-up. Counts of Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum and Aggregatibacter Actinomycetemcomitans were determined before SRP and at 4- and 6-months follow-up.
All patients had grade-B periodontitis. There was no statistically significant difference in age and gender in all groups. At- 6-months' follow-up, patients that underwent SRP once showed significantly higher counts of periodontopathogenic bacteria in the oral biofilm compared with patients that received photobiomodulation twice or three times (P < 0.05). There was no significant difference in the periodontal parameters and counts of gram-negative bacteria in patients that received photobiomodulation 2 or 3 times.
At least 2 sessions of PDT following baseline SRP is essential to achieve a significant reduction in the counts of subgingival bacteria in periodontitis patients over a 6-month follow-up period.
本为期 6 个月的随访研究旨在评估光动力疗法（PDT）作为辅助牙周基础治疗（SRP）单次与多次治疗对牙周病致病菌的影响。
共纳入 45 例牙周炎患者。患者被随机分为 3 组。在第 1 组（n = 15）、第 2 组（n = 15）和第 3 组（n = 15）中，患者在基线时、1 个月后和 1-3 个月后分别接受 SRP 和 PDT。在基线和 6 个月随访时，测量牙周探诊菌斑指数（PI）、探诊出血（BOP）、探诊深度（PD）、临床附着丧失（CAL）和边缘骨丧失（MBL）。在 SRP 前后以及 4 个月和 6 个月随访时，检测龈下菌斑中牙龈卟啉单胞菌、中间普氏菌、纤毛动弯杆菌、核梭杆菌和伴放线放线杆菌的数量。
所有患者均患有 B 级牙周炎。各组间在年龄和性别方面无统计学差异。在 6 个月随访时，与接受 2 次或 3 次光生物调节治疗的患者相比，仅接受一次 SRP 治疗的患者口腔生物膜中牙周致病菌的数量显著更高（P < 0.05）。接受 2 次或 3 次光生物调节治疗的患者牙周参数和革兰氏阴性菌数量无显著差异。
在基线 SRP 后至少进行 2 次 PDT 治疗，对于在 6 个月随访期间降低牙周炎患者龈下细菌数量至关重要。
