Department of Basic Medical Science, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102170. doi: 10.1016/j.pdpdt.2020.102170. Epub 2021 Jan 2.
It is hypothesized that scaling and root planning (SRP) with adjunct photodynamic therapy (PDT) is more effective in reducing Campylobacter rectus (C. rectus) from the oral biofilm (OB) among patients with periodontitis, than SRP alone. The objective was to compare the effectiveness of SRP with and without adjunct PDT in reducing OB C. rectus counts of patients with periodontitis.
Chronic gastritis patients diagnosed with periodontitis were included. Therapeutically, the patients were divided into 2-groups. Patients in the test- and control-groups underwent SRP with and without adjunct PDT, respectively. In both groups, full-mouth plaque index (PI), bleeding on probing (BOP), probing depth (PD) and marginal bone loss (MBL) were measured and subgingival OB counts of C. rectus were measured at baseline and 12-weeks after treatment. Data normality was assessed and group-comparisons were done using the paired t-test and Man-Whitney U tests. A type-1 error rate of 5 % was used.
Thirty patients with periodontitis were included. All patients had Grade-B/Stage-II periodontitis. All participants were male with no significant difference in age. At baseline PI, BOP, PD and MBL were comparable in both groups. Counts of C. rectus in the subgingival OB samples were similar in both groups at baseline. At 12-weeks of follow-up, PI (P < 0.01), GI (P < 0.01) and PD (P < 0.01) were significantly higher in the control- compared with the test-group compared with baseline. The percentages of C. rectus -positive individuals were higher in the control- than the test-group at 12-weeks' (P < 0.01). At 12-weeks' follow-up the percentages of C. rectus -positive patients were comparable with their respective baseline percentages in the control-group.
Compared with SRP alone, adjuvant use of PDT is more efficient in eliminating C. rectus in the OB and reducing clinical parameters in patients with grade-B/Stage-II periodontitis.
有假说称，相较于单独的牙周刮治和根面平整（SRP），牙周刮治和根面平整联合光动力疗法（PDT）能更有效地减少牙周炎患者口腔生物膜（OB）中的直肠弯曲杆菌（C. rectus）。本研究旨在比较牙周刮治和根面平整联合或不联合 PDT 辅助治疗对减少牙周炎患者 OB 中 C. rectus 计数的效果。
纳入诊断为慢性牙周炎的慢性胃炎患者。治疗上，患者被分为两组。实验组和对照组分别接受牙周刮治和根面平整联合 PDT 辅助治疗。两组均测量全口菌斑指数（PI）、探诊出血（BOP）、探诊深度（PD）和边缘骨丧失（MBL），并在基线和治疗 12 周后测量龈下 OB 中 C. rectus 的数量。评估数据正态性，采用配对 t 检验和曼-惠特尼 U 检验进行组间比较。采用 5%的Ⅰ类错误率。
共纳入 30 例慢性牙周炎患者。所有患者均为 B 级/Ⅱ期牙周炎。所有参与者均为男性，年龄无显著差异。基线时，两组的 PI、BOP、PD 和 MBL 相似。两组基线时龈下 OB 样本中的 C. rectus 计数相似。随访 12 周时，对照组的 PI（P < 0.01）、GI（P < 0.01）和 PD（P < 0.01）均显著高于实验组，与基线相比。12 周时，对照组的 C. rectus 阳性个体比例高于实验组（P < 0.01）。12 周随访时，对照组 C. rectus 阳性患者的比例与基线时的相应比例相当。
与单独的 SRP 相比，PDT 辅助治疗更能有效地消除 OB 中的 C. rectus，并减少 B 级/Ⅱ期牙周炎患者的临床参数。
