• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名免疫功能正常的新冠肺炎患者出现病毒长期脱落。

Prolonged viral shedding in an immunocompetent patient with COVID-19.

作者信息

McKie Anthony Michael, Jones Timothy Peter Wynne, Sykes Catriona

机构信息

Infectious Diseases, Monklands Hospital, Airdrie, UK

Infectious Diseases, Monklands Hospital, Airdrie, UK.

出版信息

BMJ Case Rep. 2020 Oct 4;13(10):e237357. doi: 10.1136/bcr-2020-237357.

DOI:10.1136/bcr-2020-237357
PMID:33012717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7536772/
Abstract

We present a case of COVID-19 in an immunocompetent patient with risk factors for severe disease who recovered after prolonged swab positivity of 61 days postsymptom onset without significant respiratory and organ dysfunction. We discuss the reasons behind her prolonged swab positivity in the context of current SARS-CoV-2 knowledge, document the trend in her inflammatory response and swab results, and discuss the implications swab positivity had on her isolation and recovery.

摘要

我们报告了一例免疫功能正常但有重症风险因素的COVID-19患者,该患者在症状出现后61天拭子检测持续呈阳性,最终康复,期间未出现明显的呼吸和器官功能障碍。我们结合当前对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的认识,探讨了她拭子检测持续阳性的原因,记录了她炎症反应和拭子检测结果的变化趋势,并讨论了拭子检测阳性对其隔离和康复的影响。

相似文献

1
Prolonged viral shedding in an immunocompetent patient with COVID-19.一名免疫功能正常的新冠肺炎患者出现病毒长期脱落。
BMJ Case Rep. 2020 Oct 4;13(10):e237357. doi: 10.1136/bcr-2020-237357.
2
Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series.《COVID-19 中的每日病毒动力学和固有及适应性免疫反应评估:病例系列》。
mSphere. 2020 Nov 11;5(6):e00827-20. doi: 10.1128/mSphere.00827-20.
3
Prolonged Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in an Obstetric Patient With Antibody Seroconversion.抗体转阳的产科患者中严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)RNA 的长时间检测。
Obstet Gynecol. 2020 Oct;136(4):838-841. doi: 10.1097/AOG.0000000000004086.
4
Coronavirus Disease 2019 Viremia, Serologies, and Clinical Course in a Case Series of Transplant Recipients.2019年冠状病毒病:移植受者病例系列中的病毒血症、血清学及临床病程
Transplant Proc. 2020 Nov;52(9):2637-2641. doi: 10.1016/j.transproceed.2020.08.042. Epub 2020 Sep 3.
5
Virological assessment of hospitalized patients with COVID-2019.住院 COVID-19 患者的病毒学评估。
Nature. 2020 May;581(7809):465-469. doi: 10.1038/s41586-020-2196-x. Epub 2020 Apr 1.
6
First case of persistent pancytopenia associated with SARS-CoV-2 bone marrow infiltration in an immunocompromised patient.免疫功能低下患者中首例与SARS-CoV-2骨髓浸润相关的持续性全血细胞减少病例。
Ann Oncol. 2020 Oct;31(10):1418-1419. doi: 10.1016/j.annonc.2020.06.016. Epub 2020 Jun 29.
7
Case Report: Viral Shedding for 60 Days in a Woman with COVID-19.病例报告:一名 COVID-19 女性患者病毒脱落 60 天。
Am J Trop Med Hyg. 2020 Jun;102(6):1210-1213. doi: 10.4269/ajtmh.20-0275.
8
Differences of Severe Acute Respiratory Syndrome Coronavirus 2 Shedding Duration in Sputum and Nasopharyngeal Swab Specimens Among Adult Inpatients With Coronavirus Disease 2019.新型冠状病毒肺炎成年住院患者痰液与鼻咽拭子标本中 2019 年冠状病毒脱落持续时间的差异。
Chest. 2020 Nov;158(5):1876-1884. doi: 10.1016/j.chest.2020.06.015. Epub 2020 Jun 20.
9
Optimizing COVID-19 Candidate Therapeutics: Thinking Without Borders.优化新冠病毒候选治疗方法:无边界思考。
Clin Transl Sci. 2020 Sep;13(5):830-834. doi: 10.1111/cts.12790. Epub 2020 May 2.
10
Telemedicine in the Care of Kidney Transplant Recipients With Coronavirus Disease 2019: Case Reports.2019年冠状病毒病肾移植受者护理中的远程医疗:病例报告。
Transplant Proc. 2020 Nov;52(9):2620-2625. doi: 10.1016/j.transproceed.2020.07.009. Epub 2020 Jul 16.

引用本文的文献

1
SARS-CoV-2 infection and seropositivity among household contacts of laboratory confirmed cases of COVID-19 in residents of Delhi, India.印度德里居民中新冠病毒确诊病例家庭接触者的严重急性呼吸综合征冠状病毒2感染及血清学阳性情况。
Prev Med Rep. 2024 Jan 10;38:102603. doi: 10.1016/j.pmedr.2024.102603. eCollection 2024 Feb.
2
Intratemporal mucormycosis: a rare COVID-19 sequelae.颞骨毛霉菌病:一种罕见的 COVID-19 后遗症。
BMJ Case Rep. 2023 Apr 12;16(4):e250533. doi: 10.1136/bcr-2022-250533.
3
COVID-19 patient characteristics and time to viral clearance: A retrospective observational study in a multiethnic population (United Arab Emirates).

本文引用的文献

1
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications.深度免疫剖析 COVID-19 患者,揭示具有治疗意义的不同免疫类型。
Science. 2020 Sep 4;369(6508). doi: 10.1126/science.abc8511. Epub 2020 Jul 15.
2
SARS-CoV-2 detection, viral load and infectivity over the course of an infection.在感染过程中对 SARS-CoV-2 的检测、病毒载量和传染性。
J Infect. 2020 Sep;81(3):357-371. doi: 10.1016/j.jinf.2020.06.067. Epub 2020 Jun 29.
3
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
COVID-19 患者特征与病毒清除时间:在多民族人群中进行的回顾性观察研究(阿拉伯联合酋长国)。
J Clin Virol. 2022 Dec;157:105297. doi: 10.1016/j.jcv.2022.105297. Epub 2022 Sep 22.
4
Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication.关于 RNA 结构在 SARS-CoV-2 复制中的重要性的经验教训和有待学习的内容。
Microbiol Mol Biol Rev. 2022 Sep 21;86(3):e0005721. doi: 10.1128/mmbr.00057-21. Epub 2022 Jul 7.
5
Is it COVID-19? The value of medicolegal autopsies during the first year of the COVID-19 pandemic.是否为 COVID-19?COVID-19 大流行第一年法医学解剖的价值。
Forensic Sci Int. 2022 Jan;330:111106. doi: 10.1016/j.forsciint.2021.111106. Epub 2021 Nov 14.
6
Coronavirus persistence in human respiratory tract and cell culture: An overview.冠状病毒在人类呼吸道和细胞培养中的持续存在:概述。
Braz J Infect Dis. 2021 Sep-Oct;25(5):101632. doi: 10.1016/j.bjid.2021.101632. Epub 2021 Oct 2.
7
An Immunocompetent Patient with High Neutralizing Antibody Titers Who Shed COVID-19 Virus for 169 days - China, 2020.一名具有高中和抗体滴度且新冠病毒持续排毒169天的免疫功能正常患者——中国,2020年
China CDC Wkly. 2021 Aug 6;3(32):688-691. doi: 10.46234/ccdcw2021.163.
8
Low Innate Immunity and Lagged Adaptive Immune Response in the Re-Tested Viral RNA Positivity of a COVID-19 Patient.COVID-19 患者再次检测到病毒 RNA 阳性时存在低固有免疫和滞后适应性免疫反应。
Front Immunol. 2021 Jul 1;12:664619. doi: 10.3389/fimmu.2021.664619. eCollection 2021.
9
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital.哥伦比亚大学欧文医学中心/纽约长老会医院的 COVID-19 神经病理学。
Brain. 2021 Oct 22;144(9):2696-2708. doi: 10.1093/brain/awab148.
10
Sustained Positivity and Reinfection With SARS-CoV-2 in Children: Does Quarantine/Isolation Period Need Reconsideration in a Pediatric Population?儿童中SARS-CoV-2的持续阳性及再感染:儿科人群中的隔离/检疫期是否需要重新考虑?
Cureus. 2020 Dec 10;12(12):e12012. doi: 10.7759/cureus.12012.
使用 ISARIC WHO 临床特征协议住院的 20133 例英国新冠患者的特征:前瞻性观察队列研究。
BMJ. 2020 May 22;369:m1985. doi: 10.1136/bmj.m1985.
4
Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 From Diagnostic Samples.从诊断样本中预测传染性严重急性呼吸综合征冠状病毒 2。
Clin Infect Dis. 2020 Dec 17;71(10):2663-2666. doi: 10.1093/cid/ciaa638.
5
Delirium: a missing piece in the COVID-19 pandemic puzzle.谵妄:新冠疫情拼图中缺失的一块。
Age Ageing. 2020 Jul 1;49(4):497-498. doi: 10.1093/ageing/afaa094.
6
Case Report: Viral Shedding for 60 Days in a Woman with COVID-19.病例报告:一名 COVID-19 女性患者病毒脱落 60 天。
Am J Trop Med Hyg. 2020 Jun;102(6):1210-1213. doi: 10.4269/ajtmh.20-0275.
7
Dynamics of anti-SARS-Cov-2 IgM and IgG antibodies among COVID-19 patients.新型冠状病毒肺炎患者中抗严重急性呼吸综合征冠状病毒2 IgM和IgG抗体的动态变化
J Infect. 2020 Aug;81(2):e55-e58. doi: 10.1016/j.jinf.2020.04.019. Epub 2020 Apr 23.
8
Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China.新型冠状病毒肺炎合并免疫抑制的肾移植受者肺炎:中国武汉 10 例确诊病例总结
Eur Urol. 2020 Jun;77(6):748-754. doi: 10.1016/j.eururo.2020.03.039. Epub 2020 Apr 18.
9
Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19).比较 52 例新型冠状病毒(SARS-CoV-2)感染性肺炎(COVID-19)患者的咽拭子和痰标本用于病毒核酸检测。
Clin Chem Lab Med. 2020 Jun 25;58(7):1089-1094. doi: 10.1515/cclm-2020-0187.
10
Temporal dynamics in viral shedding and transmissibility of COVID-19.新冠病毒脱落和传播的时间动态。
Nat Med. 2020 May;26(5):672-675. doi: 10.1038/s41591-020-0869-5. Epub 2020 Apr 15.