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套细胞淋巴瘤:腭肿胀的罕见病因。

Mantle cell lymphoma: a rare cause for a swollen palate.

机构信息

Oral Medicine, University of Bristol Dental Hospital, Bristol, UK

Oral Medicine, University of Bristol Dental Hospital, Bristol, UK.

出版信息

BMJ Case Rep. 2020 Oct 4;13(10):e238332. doi: 10.1136/bcr-2020-238332.

DOI:10.1136/bcr-2020-238332
PMID:33012718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7536779/
Abstract

We describe the case of a 68-year-old woman who was referred to the Oral Medicine Department in the Bristol Dental Hospital in November 2018 regarding a mass in the hard palate. The patient was previously diagnosed with stage IV mantle cell lymphoma of the upper tarsal conjunctiva in December 2014. Further investigations revealed lymphomatous deposits in other sites throughout the body. This patient underwent six cycles of chemotherapy, followed by consolidation LACE autograph and maintenance rituximab. While mantle cell lymphoma very rarely presents on the hard palate, knowledge of its clinical features and differential diagnoses is imperative in its accurate diagnosis and appropriate management.

摘要

我们描述了一位 68 岁女性的病例,她于 2018 年 11 月因硬腭肿块被转介到布里斯托尔牙科医院的口腔医学科。该患者此前于 2014 年 12 月被诊断为上眼睑结膜 IV 期套细胞淋巴瘤。进一步的检查显示全身其他部位有淋巴瘤沉积。该患者接受了六个周期的化疗,随后进行了 LACE 自体巩固治疗和利妥昔单抗维持治疗。虽然硬腭很少出现套细胞淋巴瘤,但了解其临床特征和鉴别诊断对于准确诊断和适当治疗至关重要。

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1
Mantle cell lymphoma: a rare cause for a swollen palate.套细胞淋巴瘤:腭肿胀的罕见病因。
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本文引用的文献

1
Current overview and treatment of mantle cell lymphoma.套细胞淋巴瘤的当前概述与治疗
F1000Res. 2018 Jul 25;7. doi: 10.12688/f1000research.14122.1. eCollection 2018.
2
Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma.套细胞淋巴瘤自体干细胞移植后利妥昔单抗的应用。
N Engl J Med. 2017 Sep 28;377(13):1250-1260. doi: 10.1056/NEJMoa1701769.
3
Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network.在年龄为 65 岁或以下的套细胞淋巴瘤(MCL Younger)患者中,在自体干细胞移植前给予高剂量阿糖胞苷联合免疫化疗:欧洲套细胞淋巴瘤网络的一项随机、开放标签、3 期试验。
Lancet. 2016 Aug 6;388(10044):565-75. doi: 10.1016/S0140-6736(16)00739-X. Epub 2016 Jun 14.
4
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma.伊布替尼治疗复发或难治性套细胞淋巴瘤中的 BTK。
N Engl J Med. 2013 Aug 8;369(6):507-16. doi: 10.1056/NEJMoa1306220. Epub 2013 Jun 19.
5
Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial.苯达莫司汀联合利妥昔单抗与 CHOP 联合利妥昔单抗作为惰性和套细胞淋巴瘤患者一线治疗的比较:一项开放标签、多中心、随机、3 期非劣效性临床试验。
Lancet. 2013 Apr 6;381(9873):1203-10. doi: 10.1016/S0140-6736(12)61763-2. Epub 2013 Feb 20.
6
Mantle cell lymphoma of the oral cavity: case series and comprehensive review of the literature.口腔套细胞淋巴瘤:病例系列及文献综述
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1):98-104. doi: 10.1016/j.tripleo.2009.08.010. Epub 2009 Oct 31.
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Therapeutic options in mantle cell lymphoma.套细胞淋巴瘤的治疗选择
Leuk Lymphoma. 2008 Mar;49(3):398-409. doi: 10.1080/10428190701851364.
8
Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern.硬腭套细胞淋巴瘤:一例报告及基于组织形态学和免疫表型模式的鉴别诊断综述
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Sep;96(3):316-20. doi: 10.1016/s1079-2104(03)00263-4.
9
Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis.头颈部淋巴样病变:淋巴细胞归巢与淋巴瘤发生的模型
Mod Pathol. 2002 Mar;15(3):255-63. doi: 10.1038/modpathol.3880521.