硬腭套细胞淋巴瘤：一例报告及基于组织形态学和免疫表型模式的鉴别诊断综述
Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern.
作者信息
Chang Chung-Che, Rowe J Jordi, Hawkins Philip, Sadeghi Ezedin M
机构信息
Medical College of Wisconsin and Marquette University, Milwaukee, Wis., USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Sep;96(3):316-20. doi: 10.1016/s1079-2104(03)00263-4.
To our knowledge, mantle cell lymphoma (MCL) has never been reported in the hard palate, but it is commonly observed in the nasopharynx and Waldeyer's tonsillar ring. MCL is characterized by a diffuse infiltrate of small lymphocytes with the expression of CD5, CD20, and cyclin D1 (Bcl-1), but not CD10. MCL presenting in the hard palate must be accurately distinguished from other forms of so-called small B-cell lymphomas-such as small lymphocytic lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue-because MCL possesses a worse prognosis. Awareness of MCL of the hard palate will prompt pathologists to perform adequate immunohistochemical analysis to aid in confirming the diagnosis.
据我们所知，硬腭从未有过套细胞淋巴瘤（MCL）的报道，但在鼻咽部和瓦尔代尔扁桃体环较为常见。MCL的特征是小淋巴细胞弥漫浸润，表达CD5、CD20和细胞周期蛋白D1（Bcl-1），但不表达CD10。硬腭出现的MCL必须与其他形式的所谓小B细胞淋巴瘤准确区分，如小淋巴细胞淋巴瘤、滤泡性淋巴瘤和黏膜相关淋巴组织结外边缘区B细胞淋巴瘤，因为MCL预后较差。认识到硬腭MCL将促使病理学家进行充分的免疫组织化学分析以协助确诊。
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