Grant Gunnar
Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm, Sweden.
Brain Res Rev. 2007 Oct;55(2):490-8. doi: 10.1016/j.brainresrev.2006.11.004. Epub 2007 Jan 9.
In 1906 the Nobel Prize in Physiology or Medicine was shared between Camillo Golgi and Ramón y Cajal in recognition of their work on the structure of the nervous system. Golgi's most impressive contribution was his method, described in 1873. This was applied in studies of the cerebellum, the olfactory bulb, hippocampus and the spinal cord. These studies together with his earlier work were included in his Opera Omnia, published in 1903. His method was highly praised by Cajal. His adherence to the reticular theory was opposed by Cajal, however, who had spelled out the neuron theory already in the late 1800s. Cajal's extraordinary contributions to the structure of the nervous system, based largely on the Golgi method and Ehrlich's methylene blue stain, were published in his Textura del Sistema Nerviosa de Hombre y de los Vertebrados, three volumes published from 1897 to 1904. Documents from the Nobel Archives reveal that Kölliker, Retzius and Fürst were the ones who proposed Golgi and Cajal for a shared prize. Golgi was nominated by Hertwig, as well. Cajal was proposed by Ziehen and Holmgren, and also by Retzius, as an alternative to a shared prize. Holmgren, who was commissioned to write the report to the Nobel Committee, found Cajal far superior to Golgi. Sundberg, asked for another evaluation, was more positive to Golgi's contributions than Holmgren. Gadelius supported Holmgren's views. The final vote gave a majority for a shared prize. The prize ceremony and the lectures were described in detail in Cajal's autobiography.
1906年,诺贝尔生理学或医学奖由卡米洛·高尔基(Camillo Golgi)和拉蒙·伊·卡哈尔(Ramón y Cajal)共同获得,以表彰他们在神经系统结构方面的研究工作。高尔基最令人印象深刻的贡献是他在1873年描述的方法。该方法被应用于小脑、嗅球、海马体和脊髓的研究。这些研究以及他早期的工作都收录在他1903年出版的《全集》(Opera Omnia)中。他的方法受到了卡哈尔的高度赞扬。然而,他对网状理论的坚持遭到了卡哈尔的反对,卡哈尔早在19世纪末就阐述了神经元理论。卡哈尔对神经系统结构的卓越贡献主要基于高尔基方法和埃利希的亚甲蓝染色法,这些贡献发表在他的《人类及脊椎动物神经系统的结构》(Textura del Sistema Nerviosa de Hombre y de los Vertebrados)一书中,该书于1897年至1904年分三卷出版。诺贝尔档案馆的文件显示,克利克(Kölliker)、雷蒂乌斯(Retzius)和富尔斯特(Fürst)是提议将高尔基和卡哈尔共同授予该奖项的人。赫特维希(Hertwig)也提名了高尔基。齐亨(Ziehen)和霍尔姆格伦(Holmgren)提议授予卡哈尔该奖项,雷蒂乌斯也提议授予卡哈尔该奖项,作为共同获奖的替代方案。受委托向诺贝尔委员会撰写报告的霍尔姆格伦发现,卡哈尔远比高尔基更优秀。被要求进行另一轮评估的桑德伯格(Sundberg)对高尔基的贡献比霍尔姆格伦更为肯定。加德柳斯(Gadelius)支持霍尔姆格伦的观点。最终投票结果是多数人赞成共同获奖。颁奖典礼和讲座在卡哈尔的自传中有详细描述。