Ontario Veterinary College Health Science Centre (Everest), Department of Clinical Studies (Castillo, Gaitero), University of Guelph, Guelph, Ontario.
Can Vet J. 2020 Oct;61(10):1060-1064.
A 3-year-old spayed female, West Highland white terrier dog was evaluated because of a 4-month history of recurrent brain clinical signs. Magnetic resonance imaging (MRI) revealed multifocal brain lesions consistent with ischemic injuries. Blood analysis was unremarkable aside from severe hypertriglyceridemia and hypercholesterolemia with no underlying cause, suggesting primary hyperlipidemia. The patient was treated for hyperlipidemia and started on a low-fat diet and omega-3 supplementation. Clinical signs resolved over the following 12 months along with improvement in lipidemia. This represents the first reported case of MRI findings suggestive of multiple cerebrovascular injuries associated with primary hyperlipidemia in a dog, and the first primary hyperlipidemia reported in a West Highland white terrier dog.
一只 3 岁已绝育的雌性西部高地白梗犬，因反复发作的脑部临床症状而就诊。磁共振成像（MRI）显示多灶性脑部病变，符合缺血性损伤。血液分析除了严重的高甘油三酯血症和高胆固醇血症外无其他异常，且无潜在病因，提示原发性高脂血症。该犬接受了高脂血症治疗，并开始低脂饮食和补充欧米伽-3。在接下来的 12 个月中，临床症状和血脂异常都得到了改善。这是首例报道的 MRI 结果提示原发性高脂血症犬存在多发性脑血管损伤的病例，也是首例报道的西部高地白梗犬原发性高脂血症病例。
