Vitale Christina L, Olby Natasha J
University of Missouri, Columbia Veterinary Medical Teaching Hospital, 4700 Hillsborough St, Raleigh, NC 27592, USA.
J Vet Intern Med. 2007 Nov-Dec;21(6):1316-22. doi: 10.1892/07-013.1.
Hypothyroidism has been associated with a variety of neurologic signs, but the mechanism for this association is not completely understood. Hypothyroidism also is associated with hyperlipidemia that predisposes to atherosclerosis, increased blood viscosity, and thromboembolic events.
The objective is to characterize neurologic signs potentially associated with hyperlipidemia and atherosclerosis in canine hypothyroidism.
This study used dogs referred to North Carolina State University Veterinary Teaching Hospital for evaluation of neurologic signs.
A retrospective study was conducted in which medical records of dogs with neurologic signs and a diagnosis of hypothyroidism and hyperlipidemia were reviewed. Details of the history, presenting signs, results of routine blood tests, thyroid tests, cerebrospinal fluid (CSF) analysis and diagnostic imaging, and response to therapy were compiled.
Three Labrador Retrievers and one Labrador Retriever cross fit the inclusion criteria. All dogs were hypothyroid and severely hyperlipidemic. Neurologic signs included tetraparesis, central and peripheral vestibular signs, facial paralysis, and paraparesis. Two dogs had an acute history and rapid resolution of signs consistent with an infarct, the presence of which was confirmed in 1 of the dogs by magnetic resonance imaging. Two dogs had chronic histories of cranial neuropathies and paraparesis. One of these dogs had evidence of iliac thrombosis and atherosclerosis on ultrasound examination. All dogs improved with thyroid hormone supplementation.
Labrador Retrievers may be predisposed to the development of severe hyperlipidemia in association with hypothyroidism. One possible consequence of severe hyperlipidemia is the development of neurologic signs due to atherosclerosis and thromboembolic events.
甲状腺功能减退与多种神经体征相关，但这种关联的机制尚未完全明确。甲状腺功能减退还与高脂血症相关，高脂血症易引发动脉粥样硬化、血液黏稠度增加和血栓栓塞事件。
旨在描述犬甲状腺功能减退中可能与高脂血症和动脉粥样硬化相关的神经体征。
本研究使用转诊至北卡罗来纳州立大学兽医教学医院评估神经体征的犬只。
进行了一项回顾性研究，回顾了有神经体征且诊断为甲状腺功能减退和高脂血症的犬只的病历。汇总了病史细节、现症体征、常规血液检查结果、甲状腺检查、脑脊液（CSF）分析和诊断性影像学检查结果以及治疗反应。
三只拉布拉多寻回犬和一只拉布拉多寻回犬杂交犬符合纳入标准。所有犬只均甲状腺功能减退且严重高脂血症。神经体征包括四肢轻瘫、中枢性和外周性前庭体征、面神经麻痹和截瘫。两只犬有急性病史且体征迅速缓解，符合梗死表现，其中一只犬经磁共振成像证实存在梗死。两只犬有慢性颅神经病变和截瘫病史。其中一只犬在超声检查中有髂静脉血栓形成和动脉粥样硬化的证据。所有犬只补充甲状腺激素后均有改善。
拉布拉多寻回犬可能易患与甲状腺功能减退相关的严重高脂血症。严重高脂血症的一个可能后果是由于动脉粥样硬化和血栓栓塞事件而出现神经体征。
