Oliveira-Ferreira Cláudia, Leuzinger-Dias Mariana, Tavares-Ferreira João, Faria Olinda, Falcão-Reis F
Ophthalmology Department, Centro Hospitalar São João, Oporto, Portugal.
Surgery and Physiology Department, Faculty of Medicine, Porto University, Oporto, Portugal.
Neuroophthalmology. 2019 Dec 12;44(5):290-293. doi: 10.1080/01658107.2019.1691242. eCollection 2020.
The aim of this retrospective study was to evaluate if, in ocular normotensive patients, at the time of diagnosis of optic nerve head drusen (ONHD), perimetric mean deviation (PMD) on visual field (VF) examination and retinal nerve fibre layer (RNFL) thickness on optical coherence tomography correlated with intraocular pressure (IOP). There was a significant association between IOP and PMD (Spearman's rho = -0.863, < .01) and between IOP and RNFL thickness (Spearman's rho = -0.630, < .01). A higher IOP was associated with a greater functional loss in the VF and a reduction in the RNFL thickness. These results suggest that a clinical trial of IOP reduction should be considered in patients with ONHD to decrease the progression of optic nerve damage over time.
这项回顾性研究的目的是评估在眼压正常的患者中，诊断为视乳头玻璃疣（ONHD）时，视野（VF）检查中的视野平均偏差（PMD）和光学相干断层扫描中的视网膜神经纤维层（RNFL）厚度是否与眼压（IOP）相关。眼压与PMD之间存在显著关联（Spearman等级相关系数rho = -0.863，P <.01），眼压与RNFL厚度之间也存在显著关联（Spearman等级相关系数rho = -0.630，P <.01）。较高的眼压与视野中更大的功能丧失以及RNFL厚度的减少相关。这些结果表明，对于患有ONHD的患者，应考虑进行降低眼压的临床试验，以减少视神经损伤随时间的进展。
