Pojda-Wilczek Dorota, Wycisło-Gawron Patrycja
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Ophthalmic Res. 2019;61(3):153-158. doi: 10.1159/000481534. Epub 2017 Oct 31.
The aim of the study was to compare optic nerve function in eyes with brinzolamide-reduced intraocular pressure (IOP) and the fellow eyes of patients with optic disk drusen (ODD).
The study comprised 34 patients with bilateral ODD but no signs of any other ocular disease. The eyes with more advanced optic neuropathy were selected for treatment with an IOP-lowering drug, carbonic anhydrase inhibitor (brinzolamide); the fellow eyes served as the control. Static perimetry, pattern electroretinography (PERG), pattern visual-evoked potentials (PVEP), and retinal nerve fiber layer (RNFL) thickness were analyzed. The observation period was 12 months.
The eyes with brinzolamide-reduced IOP exhibited a statistically significant decrease in the mean defect index of static visual field (p = 0.03), an increase in PERG N95 amplitude (from 2.94 to 4.41 µV; p = 0.0047), and RNFL thickness stabilization. A statistically significant decrease in RNFL thickness (from 83.21 to 79.85 µm; p = 0.0017) was found in the control eyes.
A decrease in IOP in eyes with ODD results in improvement of retinal ganglion cell function and delays the progression of optic neuropathy. PERG should be performed in patients with ODD as it is a sensitive test for monitoring optic neuropathy.
本研究旨在比较使用布林佐胺降低眼压的患眼与患有视盘小凹（ODD）患者对侧眼的视神经功能。
本研究纳入34例双侧患有ODD但无任何其他眼部疾病体征的患者。选择视神经病变更严重的患眼使用降眼压药物碳酸酐酶抑制剂（布林佐胺）进行治疗；对侧眼作为对照。分析了静态视野检查、图形视网膜电图（PERG）、图形视觉诱发电位（PVEP）和视网膜神经纤维层（RNFL）厚度。观察期为12个月。
使用布林佐胺降低眼压的患眼静态视野平均缺损指数有统计学意义的下降（p = 0.03），PERG N95波幅增加（从2.94 μV增至4.41 μV；p = 0.0047），且RNFL厚度稳定。对照眼中RNFL厚度有统计学意义的下降（从83.21 µm降至79.85 µm；p = 0.0017）。
ODD患眼眼压降低可改善视网膜神经节细胞功能并延缓视神经病变进展。ODD患者应进行PERG检查，因为它是监测视神经病变的敏感检查。
