Koçak Nurullah, Yeter Volkan, Güngör Inci
Ophthalmology Department, Ondokuz Mayis University Hospital, Samsun, Turkey.
Neuroophthalmology. 2020 Mar 18;44(5):294-298. doi: 10.1080/01658107.2020.1733618. eCollection 2020.
The purpose of this study was to evaluate the monocyte to high-density lipoprotein (HDL) ratio (MHR) in patients with arteritic anterior ischaemic optic neuropathy (A-AION) and non-arteritic anterior ischaemic optic neuropathy (NA-AION). A total of 98 subjects were included in the study. Patients were divided into three groups: 16 patients with A-AION regarded as group one; 41 patients with NA-AION regarded as group two and 41 healthy subjects regarded as the control group. The MHR was calculated in all participants and compared between the patient and control groups. The mean age of subjects with A-AION, NA-AION and the control group were 75.9 ± 8.9 years, 67.1 ± 9.2 years, and 66.6 ± 6.7 years, respectively. Baseline clinical characteristics, such as diabetes mellitus and hypertension, were similar among groups. The mean MHR was significantly higher only in the A-AION group compared with the NA-AION and control group ( < .001), whereas there was no difference between NA-AION group and control group ( = .110). On receiver operating characteristic analysis, the area under the curve was 0.755, and the best cut- off value was 12.2 with a sensitivity of 72% and a specificity of 80%. An elevated MHR ratio is significantly associated with A-AION and MHR might be used to differentiate A-AION from NA-AION.
本研究旨在评估动脉炎性前部缺血性视神经病变（A-AION）和非动脉炎性前部缺血性视神经病变（NA-AION）患者的单核细胞与高密度脂蛋白（HDL）比值（MHR）。共有98名受试者纳入本研究。患者被分为三组：16例A-AION患者作为第一组；41例NA-AION患者作为第二组；41名健康受试者作为对照组。计算所有参与者的MHR，并在患者组和对照组之间进行比较。A-AION组、NA-AION组和对照组受试者的平均年龄分别为75.9±8.9岁、67.1±9.2岁和66.6±6.7岁。各组间基线临床特征，如糖尿病和高血压，相似。与NA-AION组和对照组相比，仅A-AION组的平均MHR显著更高（<.001），而NA-AION组和对照组之间无差异（=.110）。在接受者操作特征分析中，曲线下面积为0.755，最佳截断值为12.2，敏感性为72%，特异性为80%。MHR升高与A-AION显著相关，MHR可用于区分A-AION与NA-AION。
