Le Nguyen Phuong Khanh, Gerdts Volker, Singh Baljit
Western College of Veterinary Medicine (Le, Gerdts, Singh) and Vaccine and Infectious Disease Organization - International Vaccine Centre (Gerdts), University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4; Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam (Le); Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 4Z6 (Singh).
Can J Vet Res. 2020 Oct;84(4):245-251.
Integrin alpha-v/beta3 (αvβ3) recognizes arginine-glycine-aspartic acid (RGD) sequences and has important functions in cell adhesion, signaling, and survival. However, the expression of integrin αvβ3 in the equine lungs and jejunum is not well understood. The objective of this study was to explore the hitherto unknown expression of integrin αvβ3 in the lungs and jejuna of the horse using light and electron immunocytochemistry. Immunohistochemistry showed integrin αvβ3 on the epithelium, the immune cells in Peyer's patches, the smooth muscle, and the endothelium of equine jejuna. In equine lungs, we recognized integrin αvβ3 on the endothelium of blood vessels, the alveolar septa, the bronchial lymph nodes, and the cartilages, although the expression of integrin αvβ3 was weak on the epithelium of bronchioles. In conclusion, these are the first data to show the expression of integrin αvβ3 in equine lungs and jejuna.
整合素α-v/β3（αvβ3）识别精氨酸-甘氨酸-天冬氨酸（RGD）序列，在细胞黏附、信号传导和存活中具有重要功能。然而，整合素αvβ3在马肺和空肠中的表达尚不清楚。本研究的目的是利用光镜和电镜免疫细胞化学方法，探索整合素αvβ3在马肺和空肠中迄今未知的表达情况。免疫组织化学显示，整合素αvβ3存在于马空肠的上皮、派尔集合淋巴结中的免疫细胞、平滑肌和内皮细胞上。在马肺中，我们在血管内皮、肺泡隔、支气管淋巴结和软骨上识别出了整合素αvβ3，尽管细支气管上皮上的整合素αvβ3表达较弱。总之，这些是首次显示整合素αvβ3在马肺和空肠中表达的数据。
