Peng Longping, Dong Yidan, Fan Hua, Cao Min, Wu Qiong, Wang Yi, Zhou Chang, Li Shuchun, Zhao Cheng, Wang Youhua
Cardiovascular Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Vascular Disease Department, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2020 Sep 3;11:1259. doi: 10.3389/fphar.2020.01259. eCollection 2020.
Lymphatic vessels, as an important part of the lymphatic system, form a fine vascular system in humans and play an important role in regulating fluid homeostasis, assisting immune surveillance and transporting dietary lipids. Dysfunction of lymphatic vessels can cause many diseases, including cancer, cardiovascular diseases, lymphedema, inflammation, rheumatoid arthritis. Research on lymphangiogenesis has become increasingly important over the last few decades. Nevertheless, the explicit role of regulating lymphangiogenesis in preventing and treating diseases remains unclear owing to the lack of a deeper understanding of the cellular and molecular pathways of the specific and tissue-specific changes in lymphangiopathy. TCM, consisting of compound extracted from TCM, Injections of single TCM and formula, is an important complementary strategy for treating disease in China. Lots of valuable traditional Chinese medicines are used as substitutes or supplements in western countries. As one of the main natural resources, these TCM are widely used in new drug research and development in Asia. Moreover, as a historical and cultural heritage, TCM has been widely applied to clinical research on lymphangiogenesis leveraging new technologies recently. Available studies show that TCM has an explicit effect on the regulation of lymphatic regeneration. This review aims to clarify the function and mechanisms, especially the inhibitory effect of TCM in facilitating and inhibiting lymphatic regeneration.
淋巴管作为淋巴系统的重要组成部分，在人体中形成一个精细的血管系统，在调节液体稳态、协助免疫监视和运输膳食脂质方面发挥着重要作用。淋巴管功能障碍可导致多种疾病，包括癌症、心血管疾病、淋巴水肿、炎症、类风湿性关节炎。在过去几十年中，淋巴管生成的研究变得越来越重要。然而，由于对淋巴管病中特定和组织特异性变化的细胞和分子途径缺乏更深入的了解，调节淋巴管生成在预防和治疗疾病中的明确作用仍不清楚。中药由从中药中提取的化合物、单一中药注射剂和配方组成，是中国治疗疾病的重要补充策略。许多有价值的中药在西方国家被用作替代品或补充剂。作为主要自然资源之一，这些中药在亚洲新药研发中被广泛应用。此外，作为一种历史文化遗产，中药最近利用新技术已广泛应用于淋巴管生成的临床研究。现有研究表明，中药对淋巴再生的调节具有明确作用。本综述旨在阐明其功能和机制，特别是中药在促进和抑制淋巴再生方面的抑制作用。
