Hagen Bjørn Ingulfsvann, Landrø Nils Inge, Lau Bjørn, Koster Ernst H W, Stubberud Jan
Department of Research, Lovisenberg Diaconal Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
Front Psychol. 2020 Sep 11;11:2232. doi: 10.3389/fpsyg.2020.02232. eCollection 2020.
Cognitive remediation (CR) techniques (interventions to enhance cognitive functioning) have proven moderately effective in improving cognition and daily functioning in major depressive disorder (MDD). However, baseline predictors of treatment response are lacking. The present study aimed to identify factors influencing long-term CR outcomes in a sample with current or previous, mild or moderate MDD and with self-reported cognitive deficits.
Forty-two completers of group-based CR (strategy learning or drill-and-practice), were pooled into one sample. Based on change scores from baseline to 6-month follow-up, participants were categorized as "improvers" or "non-improvers" using reliable change index calculations. Measures included a questionnaire of everyday executive functioning and a neuropsychological test of attention. Finally, improvers and non-improvers were compared in terms of various sociodemographic, psychological, illness-related, and neuropsychological baseline variables.
Seventeen participants improved reliably in everyday executive functioning, and fourteen demonstrated a reliable improvement in attention. No statistically significant differences emerged between improvers and non-improvers.
No major predictors of CR were identified. Importantly, the current findings are insufficient to guide clinical decision-making. Large-scale studies with hypotheses are needed to make advances in the future.
认知康复（CR）技术（旨在增强认知功能的干预措施）已被证明在改善重度抑郁症（MDD）的认知和日常功能方面有一定效果。然而，目前尚缺乏治疗反应的基线预测指标。本研究旨在确定在患有当前或既往轻度或中度MDD且自我报告存在认知缺陷的样本中，影响CR长期效果的因素。
将42名基于小组的CR（策略学习或练习与实践）完成者纳入一个样本。根据从基线到6个月随访的变化分数，使用可靠变化指数计算将参与者分为“改善者”或“未改善者”。测量指标包括日常执行功能问卷和注意力神经心理学测试。最后，比较改善者和未改善者在各种社会人口统计学、心理、疾病相关和神经心理学基线变量方面的差异。
17名参与者在日常执行功能方面有可靠改善，14名在注意力方面有可靠改善。改善者和未改善者之间未出现统计学上的显著差异。
未确定CR的主要预测指标。重要的是，目前的研究结果不足以指导临床决策。未来需要进行有假设的大规模研究以取得进展。
