Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Changsha, China.
Front Immunol. 2020 Aug 18;11:1757. doi: 10.3389/fimmu.2020.01757. eCollection 2020.
The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression.
该 pentraxin 是一种具有相同结构域的蛋白质超家族，该结构域在 C 末端被称为 pentraxin 结构域。该家族有两个亚群，即短 pentraxins（C 反应蛋白和血清淀粉样蛋白 P 成分）和长 pentraxins（神经 pentraxin 1、神经 pentraxin 2、神经 pentraxin 受体、pentraxin 3 和 pentraxin 4）。每个亚群的结构都相似，五聚体复合物呈盘状排列。先前的研究揭示了不同 pentraxin 家族成员的功能。它们大多数与人类先天免疫有关。炎症通常与肿瘤进展有关，这意味着 pentraxin 家族也可能参与肿瘤进展。因此，我们综述了 pentraxin 家族的基本特征和功能及其在肿瘤进展中的作用。
