Inserm U1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Hôpital Pitié-Salpêtrière, AP-HP, Sorbonne Université, Paris, France.
Unité de Transplantation Hépatique, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France.
Front Immunol. 2020 Sep 2;11:2005. doi: 10.3389/fimmu.2020.02005. eCollection 2020.
Regulatory T (Treg) cells expressing the FOXP3 transcription factor are presently under investigation by many teams globally as a cellular therapy to induce tolerance in transplantation. This is primarily due to their immunosuppressive and homeostatic functions. Depending on the type of allograft, Treg cells will need to infiltrate and function in metabolically diverse microenvironments. This means that any resident and circulating Treg cells need to differentially adapt to counter acute or chronic allograft rejection. However, the links between Treg cell metabolism and function are still not entirely delineated. Current data suggest that Treg cells and their effector counterparts have different metabolite dependencies and metabolic programs. These properties could be exploited to optimize intragraft Treg cell function. In this review, we discuss the current paradigms regarding Treg cell metabolism and outline critical intracellular axes that link metabolism and function. Finally, we discuss how this knowledge could be clinically translated for the benefit of transplant patients.
调节性 T（Treg）细胞表达 FOXP3 转录因子，目前全球许多团队都在研究其作为诱导移植耐受的细胞疗法。这主要是由于其免疫抑制和稳态功能。根据同种异体移植物的类型，Treg 细胞需要浸润并在代谢多样化的微环境中发挥作用。这意味着任何常驻和循环的 Treg 细胞都需要不同地适应以对抗急性或慢性同种异体排斥反应。然而，Treg 细胞代谢与功能之间的联系尚未完全阐明。目前的数据表明，Treg 细胞及其效应细胞具有不同的代谢物依赖性和代谢程序。这些特性可被利用来优化移植物内 Treg 细胞的功能。在这篇综述中，我们讨论了 Treg 细胞代谢的当前范例，并概述了将代谢与功能联系起来的关键细胞内轴。最后，我们讨论了如何将这些知识转化为临床应用，使移植患者受益。
