• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

治疗性HL隐形眼镜与标准绷带式隐形眼镜治疗角膜水肿的前瞻性、多中心、随机、交叉研究。

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.

作者信息

Daphna Ofer, Mimouni Michael, Keshet Yariv, Ben Ishai Meydan, Barequet Irina S, Knyazer Boris, Mrukwa-Kominek Ewa, Zarnowski Tomasz, Chen-Zion Malca, Marcovich Arie

机构信息

EyeYon Medical, Ness Tziona, Israel.

Department of Ophthalmology, Rambam Health Care Campus, Affiliated to the Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

出版信息

J Ophthalmol. 2020 Sep 21;2020:8410920. doi: 10.1155/2020/8410920. eCollection 2020.

DOI:10.1155/2020/8410920
PMID:33014443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7525312/
Abstract

INTRODUCTION

To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema.

METHODS

Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the second arm was fitted with a standard soft bandage contact lens. Both arms were treated with 5% sodium chloride 6 times a day. After a 7-day treatment period, there was a 7-day washout period, after which the arms were crossed over. Patients were evaluated at days 0 (baseline), 7 (following first treatment allocation), 14 (following washout), and 21 (following second treatment allocation). The primary outcomes were 3 lines of BCVA (best corrected visual acuity) improvement.

RESULTS

In total, 49 patients were enrolled. There was significantly greater BCVA improvement rate >3 lines (30.4% versus 17.4%, =0.04) in the Therapeutic Hyper-CL™ lens group. The mean change in BCVA lines was significantly greater for the Therapeutic Hyper-CL™ lens (3.4 ± 6.7 versus 0.9 ± 2.3, =0.02).

CONCLUSIONS

The Therapeutic Hyper-CL™ lens was associated with a higher chance for significant visual acuity improvement when compared to a standard bandage contact lens combined with 5% sodium chloride. This trial is registered with NCT02660151.

摘要

引言

比较Therapeutic Hyper-CL™镜片与标准绷带式隐形眼镜（PureVision B&L）治疗慢性角膜水肿的安全性和有效性。

方法

前瞻性、多中心、随机、交叉研究。慢性角膜水肿患者被随机分为两组。第一组佩戴Therapeutic Hyper-CL™镜片，第二组佩戴标准软性绷带式隐形眼镜。两组均每天使用6次5%氯化钠溶液。经过7天的治疗期后，有7天的洗脱期，之后两组进行交叉。在第0天（基线）、第7天（首次治疗分配后）、第14天（洗脱期后）和第21天（第二次治疗分配后）对患者进行评估。主要结局指标为最佳矫正视力（BCVA）提高3行。

结果

共纳入49例患者。Therapeutic Hyper-CL™镜片组的BCVA提高率>3行的情况显著更多（30.4%对17.4%，P=0.04）。Therapeutic Hyper-CL™镜片组的BCVA行数平均变化显著更大（3.4±6.7对0.9±2.3，P=0.02）。

结论

与标准绷带式隐形眼镜联合5%氯化钠溶液相比，Therapeutic Hyper-CL™镜片显著提高视力的可能性更高。本试验已在ClinicalTrials.gov注册，注册号为NCT02660151。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/63fea88011ab/joph2020-8410920.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/4477408dc185/joph2020-8410920.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/a5afdecba334/joph2020-8410920.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/63fea88011ab/joph2020-8410920.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/4477408dc185/joph2020-8410920.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/a5afdecba334/joph2020-8410920.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a358/7525312/63fea88011ab/joph2020-8410920.003.jpg

相似文献

1
Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.治疗性HL隐形眼镜与标准绷带式隐形眼镜治疗角膜水肿的前瞻性、多中心、随机、交叉研究。
J Ophthalmol. 2020 Sep 21;2020:8410920. doi: 10.1155/2020/8410920. eCollection 2020.
2
Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome.治疗性高渗性软性角膜接触镜在干燥综合征中的应用
Am J Ophthalmol Case Rep. 2022 Aug 19;28:101685. doi: 10.1016/j.ajoc.2022.101685. eCollection 2022 Dec.
3
Therapeutic contact lens for Fuchs endothelial corneal dystrophy: Monitoring with Scheimpflug tomography.用于富克斯内皮性角膜营养不良的治疗性隐形眼镜：通过Scheimpflug断层扫描进行监测。
Am J Ophthalmol Case Rep. 2021 Dec 9;25:101242. doi: 10.1016/j.ajoc.2021.101242. eCollection 2022 Mar.
4
Efficacy of continuous wear PureVision contact lenses for therapeutic use.连续佩戴用于治疗目的的 PureVision 隐形眼镜的疗效。
Cont Lens Anterior Eye. 2004 Mar;27(1):39-43. doi: 10.1016/j.clae.2003.09.004.
5
Therapeutic use of Bausch & Lomb PureVision contact lenses.博士伦纯视隐形眼镜的治疗用途。
CLAO J. 2001 Oct;27(4):179-85.
6
Comparative study of two silicone hydrogel contact lenses used as bandage contact lenses after LASEK.两种硅水凝胶隐形眼镜作为LASEK术后绷带镜的对比研究。
Optom Vis Sci. 2008 Sep;85(9):884-8. doi: 10.1097/OPX.0b013e31818527fd.
7
Efficacy of Anterior Stromal Puncture Surgery with Corneal Bandage Lens for Bullous Keratopathy.前弹力层穿刺联合角膜绷带镜治疗大泡性角膜病变的疗效。
Int J Med Sci. 2019 May 7;16(5):660-664. doi: 10.7150/ijms.31669. eCollection 2019.
8
Masked comparison of two silicone hydrogel bandage contact lenses after photorefractive keratectomy.经光折射性角膜切削术后两种硅水凝胶绷带接触镜的蒙眼比较。
Cont Lens Anterior Eye. 2020 Jun;43(3):244-249. doi: 10.1016/j.clae.2020.02.005. Epub 2020 Feb 23.
9
Comparison of silicone and non-silicone hydrogel soft contact lenses used as a bandage after LASEK.准分子激光上皮下角膜磨镶术（LASEK）后用作绷带的硅水凝胶和非硅水凝胶软性接触镜的比较。
J Refract Surg. 2008 Feb;24(2):199-203. doi: 10.3928/1081597X-20080201-12.
10
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses.圆锥角膜患者佩戴Toris K软性角膜接触镜的视力矫正与安全性回顾性分析
Int Ophthalmol. 2016 Dec;36(6):799-805. doi: 10.1007/s10792-016-0200-0. Epub 2016 Feb 19.

引用本文的文献

1
Managing pseudophakic bullous keratopathy with a topical rho kinase inhibitor: a case series.使用局部 Rho 激酶抑制剂治疗人工晶状体性大泡性角膜病变：病例系列
J Med Case Rep. 2025 May 8;19(1):214. doi: 10.1186/s13256-025-05263-6.
2
Contact lenses in dry eye disease and associated ocular surface disorders.干眼症和相关眼表疾病中的隐形眼镜。
Indian J Ophthalmol. 2023 Apr;71(4):1142-1153. doi: 10.4103/IJO.IJO_2778_22.
3
Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome.治疗性高渗性软性角膜接触镜在干燥综合征中的应用

本文引用的文献

1
Limbal Metabolic Support Reduces Peripheral Corneal Edema with Contact-Lens Wear.角膜缘代谢支持可减轻佩戴隐形眼镜时的周边角膜水肿。
Transl Vis Sci Technol. 2020 Jun 30;9(7):44. doi: 10.1167/tvst.9.7.44. eCollection 2020 Jun.
2
Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury.上皮细胞衍生的 IL-33 通过激活肥大细胞来启动角膜损伤后的中性粒细胞募集。
Ocul Surf. 2020 Oct;18(4):633-640. doi: 10.1016/j.jtos.2020.06.006. Epub 2020 Jun 29.
3
Corneal endothelial cell dysfunction: etiologies and management.
Am J Ophthalmol Case Rep. 2022 Aug 19;28:101685. doi: 10.1016/j.ajoc.2022.101685. eCollection 2022 Dec.
4
Therapeutic contact lens for Fuchs endothelial corneal dystrophy: Monitoring with Scheimpflug tomography.用于富克斯内皮性角膜营养不良的治疗性隐形眼镜：通过Scheimpflug断层扫描进行监测。
Am J Ophthalmol Case Rep. 2021 Dec 9;25:101242. doi: 10.1016/j.ajoc.2021.101242. eCollection 2022 Mar.
5
Therapeutic Ophthalmic Lenses: A Review.治疗性眼科镜片：综述
Pharmaceutics. 2020 Dec 28;13(1):36. doi: 10.3390/pharmaceutics13010036.
角膜内皮细胞功能障碍：病因与治疗
Ther Adv Ophthalmol. 2018 Dec 7;10:2515841418815802. doi: 10.1177/2515841418815802. eCollection 2018 Jan-Dec.
4
Global Survey of Corneal Transplantation and Eye Banking.全球角膜移植与眼库调查
JAMA Ophthalmol. 2016 Feb;134(2):167-73. doi: 10.1001/jamaophthalmol.2015.4776.
5
Corneal structure and transparency.角膜结构与透明度。
Prog Retin Eye Res. 2015 Nov;49:1-16. doi: 10.1016/j.preteyeres.2015.07.001. Epub 2015 Jul 2.
6
Alternatives to corneal transplantation for the management of bullous keratopathy.治疗大泡性角膜病变的角膜移植替代疗法。
Curr Opin Ophthalmol. 2014 Jul;25(4):347-52. doi: 10.1097/ICU.0000000000000062.
7
Molecular mechanisms underlying the corneal endothelial pump.角膜内皮泵的分子机制。
Exp Eye Res. 2012 Feb;95(1):2-7. doi: 10.1016/j.exer.2011.06.004. Epub 2011 Jun 15.
8
Role of cysteine in corneal wound healing after photorefractive keratectomy.半胱氨酸在准分子激光原位角膜磨镶术后角膜伤口愈合中的作用。
Ophthalmic Res. 2009;41(2):76-82. doi: 10.1159/000187623. Epub 2008 Dec 20.
9
Effect of basic fibroblast growth factor in transgenic mice: corneal epithelial healing process after excimer laser photoablation.碱性成纤维细胞生长因子在转基因小鼠中的作用：准分子激光光消融术后角膜上皮愈合过程
Ophthalmologica. 2009;223(2):139-44. doi: 10.1159/000187686. Epub 2008 Dec 18.
10
Comparison of conventional and silicone hydrogel contact lenses for bullous keratoplasty.用于大疱性角膜移植术的传统隐形眼镜与硅水凝胶隐形眼镜的比较。
Eye Contact Lens. 2006 Sep;32(5):250-3. doi: 10.1097/01.icl.0000219499.24304.d3.