中性粒细胞氧化修饰蛋白和中性粒细胞胞外诱捕网在社区获得性肺炎患者中的变化。
Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia.
机构信息
"Karaganda Medical University" Non-commercial Joint-Stock Company, Kazakhstan.
Pavlodar State Pedagogical University, Kazakhstan.
出版信息
Pulm Med. 2020 Sep 15;2020:4897038. doi: 10.1155/2020/4897038. eCollection 2020.
MATERIALS AND METHODS
51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers.
RESULTS
Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups.
CONCLUSION
Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.
材料与方法
根据疾病过程的严重程度，51 例 CAP 患者被分为 2 组。第一组（I）包括 32 例中度肺炎患者。第二组（II）包括 19 例重症肺炎患者。第三组（III）为比较组，由 14 例合并慢性阻塞性肺疾病（COPD）的 CAP 患者组成。对照组由 19 名志愿者组成。
结果
与对照组相比，所有研究组的羰基衍生物（CD）水平均显著升高。在中度和重度肺炎患者组中，以及在合并 COPD 的 CAP 患者中，CD 水平均高于对照组。在研究组之间，血液中性粒细胞中的晚期氧化蛋白产物（AOPP）和髓过氧化物酶（MPO）水平没有统计学差异。
结论
结果表明中性粒细胞中存在氧化失衡，并导致疾病恶化。
Zotero 插件